Evidence map›Paper›PMID 27827950›Full record

ArticleToxins2016

Tenuifolide B from Cinnamomum tenuifolium Stem Selectively Inhibits Proliferation of Oral Cancer Cells via Apoptosis, ROS Generation, Mitochondrial Depolarization, and DNA Damage.

Chung-Yi Chen, Ching-Yu Yen, Hui-Ru Wang, Hui-Ping Yang, Jen-Yang Tang, Hurng-Wern Huang, Shih-Hsien Hsu, Hsueh-Wei Chang

Open access · goldAbstract read
In one paragraph

Article in Toxins, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
3.3field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 53 citations in OpenAlex.

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  16. Antioxidants (Basel, Switzerland) · 2021
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  19. Combined Treatment with Low Cytotoxic Ethyl AcetateAntioxidants (Basel, Switzerland) · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Chung-Yi ChenDepartment of Nutrition and Health Sciences, School of Medical and Health Sciences, Fooyin University, Kaohsiung 83102, Taiwan. XX377@fy.edu.tw.
Ching-Yu YenDepartment of Oral and Maxillofacial Surgery Chi-Mei Medical Center, Tainan 71004, Taiwan. ycysmc@gmail.com.
Hui-Ru WangDepartment of Biomedical Science and Environmental Biology, Kaohsiung Medical University, Kaohsiung 80708, Taiwan. whr0319@gmail.com.
Hui-Ping YangGraduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan. kayyang1950@yahoo.com.tw.
Jen-Yang TangDepartment of Radiation Oncology, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan. reyata@kmu.edu.tw.
Hurng-Wern HuangInstitute of Biomedical Science, National Sun Yat-Sen University, Kaohsiung 80424, Taiwan. sting@mail.nsysu.edu.tw.
Shih-Hsien HsuGraduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan. jackhsu@kmu.edu.tw.
Hsueh-Wei ChangDepartment of Biomedical Science and Environmental Biology, Kaohsiung Medical University, Kaohsiung 80708, Taiwan. changhw@kmu.edu.tw.
Kaohsiung Medical University · TWNational Sun Yat-sen University · TWChi Mei Medical Center · TWFooyin University · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The development of drugs that selectively kill oral cancer cells but are less harmful to normal cells still provide several challenges. In this study, the antioral cancer effects of tenuifolide B (TFB), extracted from the stem of the plant

Indexed as

Cinnamomum4-ButyrolactoneAntineoplastic AgentsCell Line, TumorCell ProliferationDNA DamageHumansMembrane Potential, MitochondrialMouth NeoplasmsPlant StemsReactive Oxygen Species4-ButyrolactoneAntineoplastic AgentsReactive Oxygen Speciestenuifolide BapoptosisDNA damagenatural productoral cancerROSselective killing

Identifiers

PMID27827950
PMCPMC5127116
OpenAlexW2548196609

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.