ReviewNutrients2016
Relationship between Added Sugars Consumption and Chronic Disease Risk Factors: Current Understanding.
Review in Nutrients, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 96 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
96 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Ultra-Processed Food Intakes and Health Outcomes in Adults Older Than 60 Years: A Systematic Review.Nutrition reviews · 2025Pooled it
- Diet Quality and Measures of Sarcopenia in Developing Economies: A Systematic Review.Nutrients · 2022Pooled it
- Genetic Background of Taste Perception, Taste Preferences, and Its Nutritional Implications: A Systematic Review.Frontiers in genetics · 2019Pooled it
- Self-selected dietary intake and association with achieved caloric restriction in CALERIECritical reviews in food science and nutrition · 2026Trial
- Exploring the effects of added sugar labels on food purchasing behaviour in Australian parents: An online randomised controlled trial.PloS one · 2022Trial
- A pilot feasibility study investigating the impact of increasing sucrose intakes on body composition and blood pressure.Journal of nutritional science · 2021Trial
- Changes in Non-Nutritive Sweetener Consumption Patterns in Response to a Sugar-Sweetened Beverage Reduction Intervention.Nutrients · 2020Trial
- Chronic sucralose consumption induces elevation of serum insulin in young healthy adults: a randomized, double blind, controlled trial.Nutrition journal · 2020Trial
- Trial
- The Use of Herbs and Spices to Improve Food Liking and Diet Quality.Nutrition reviews · 2026Review
- Birthplace and nutrient intake across ethnic subgroups: a cross-sectional analysis of the NHANES.The American journal of clinical nutrition · 2026Article
- Nutritional contents, nutritional quality and manufacturer of ready foods in China: a cross-sectional study of 2087 food products.Nutrition & diabetes · 2026Article
- Free Sugars Consumption and Type 2 Diabetes: What Are the Concerns and How Strong is the Evidence?Current nutrition reports · 2026Review
- Long-term sugar consumption alters extracellular dopamine and acetylcholine levels in the nucleus accumbens shell.Frontiers in behavioral neuroscience · 2026Article
- New Insight Into Male Infertility: Deviation From Basic Tenets of Life.Oxidative medicine and cellular longevity · 2026Review
- Ultra-Processed Foods and Metabolic Dysfunction: A Narrative Review of Dietary Processing, Behavioral Drivers and Chronic Disease Risk.Metabolites · 2025Review
- Ultra-processed food intake is associated with altered glucose homeostasis in young adults with a history of overweight or obesity: a longitudinal study.Nutrition & metabolism · 2025Article
- Hyperspectral Imaging for Quality Assessment of Processed Foods: A Case Study on Sugar Content in Apple Jam.Foods (Basel, Switzerland) · 2025Article
- Development of Fructooligosaccharide-Rich Sugarcane Juice by Enzymatic Method and Enhancement of Its Microbial Safety Using High-Pressure Processing.Foods (Basel, Switzerland) · 2025Article
- Beyond Sugar: A Holistic Review of Sweeteners and Their Role in Modern Nutrition.Foods (Basel, Switzerland) · 2025Review
36 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Added sugars are a controversial and hotly debated topic. Consumption of added sugars has been implicated in increased risk of a variety of chronic diseases including obesity, cardiovascular disease, diabetes and non-alcoholic fatty liver disease (NAFLD) as well as cognitive decline and even some cancers. Support for these putative associations has been challenged, however, on a variety of fronts. The purpose of the current review is to summarize high impact evidence including systematic reviews, meta-analyses, and randomized controlled trials (RCTs), in an attempt to provide an overview of current evidence related to added sugars and health considerations. This paper is an extension of a symposium held at the Experimental Biology 2015 conference entitled "Sweeteners and Health: Current Understandings, Controversies, Recent Research Findings and Directions for Future Research". We conclude based on high quality evidence from randomized controlled trials (RCT), systematic reviews and meta-analyses of cohort studies that singling out added sugars as unique culprits for metabolically based diseases such as obesity, diabetes and cardiovascular disease appears inconsistent with modern, high quality evidence and is very unlikely to yield health benefits. While it is prudent to consume added sugars in moderation, the reduction of these components of the diet without other reductions of caloric sources seems unlikely to achieve any meaningful benefit.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.