ArticleMolecules (Basel, Switzerland)2016
Cytotoxic, Antitumor and Immunomodulatory Effects of the Water-Soluble Polysaccharides from Lotus (Nelumbo nucifera Gaertn.) Seeds.
Article in Molecules (Basel, Switzerland), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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Who cites it
12 citing papers in PubMed, 38 citations in OpenAlex.
- Evaluating the Therapeutic Potential of Antioxidants in Polyendocrine Metabolic Ovarian Syndrome (PMOS)-Associated Infertility.International journal of women's health · 2026Review
- A review on extraction, composition, structure, and biological activities of polysaccharides from different parts ofFood science & nutrition · 2023Review
- Article
- Bioactive polysaccharides from lotus as potent food supplements: a review of their preparation, structures, biological features and application prospects.Frontiers in nutrition · 2023Review
- Lotus (Cancers · 2022Review
- Clinical and Biochemical Potential of Antioxidants in Treating Polycystic Ovary Syndrome.International journal of women's health · 2022Review
- A comparative review on the anti-nutritional factors of herbal tea concoctions and their reduction strategies.Frontiers in nutrition · 2022Review
- Phytochemicals and Immunomodulatory Effect ofPlants (Basel, Switzerland) · 2021Article
- The investigation of immunomodulatory activities ofExperimental and therapeutic medicine · 2018Article
- Molecular Structure-Affinity Relationship of Flavonoids in Lotus Leaf (Nelumbo nucifera Gaertn.) on Binding to Human Serum Albumin and Bovine Serum Albumin by Spectroscopic Method.Molecules (Basel, Switzerland) · 2017Article
- Separation of Oligosaccharides from Lotus Seeds via Medium-pressure Liquid Chromatography Coupled with ELSD and DAD.Scientific reports · 2017Article
- Anti-Cancerous Potential of Polysaccharide Fractions Extracted from Peony Seed Dreg on Various Human Cancer Cell Lines Via Cell Cycle Arrest and Apoptosis.Frontiers in pharmacology · 2017Article
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Lotus is an edible and medicinal plant, and the extracts from its different parts exhibit various bioactivities. In the present study, the hot water-soluble polysaccharides from lotus seeds (LSPS) were evaluated for their cancer cell cytotoxicity, immunomodulatory and antitumor activities. LSPS showed significant inhibitory effects on the mouse gastric cancer MFC cells, human liver cancer HuH-7 cells and mouse hepatocarcinoma H22 cells. The animal studies showed that LSPS inhibited tumor growth in H22 tumor-bearing mice with the highest inhibition rate of 45.36%, which is comparable to that induced by cyclophosphamide (30 mg/kg) treatment (50.79%). The concentrations of white blood cells were significantly reduced in cyclophosphamide-treated groups (
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.