ArticleDevelopment (Cambridge, England)2016
Nodal and FGF coordinate ascidian neural tube morphogenesis.
Article in Development (Cambridge, England), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 29 citations in OpenAlex.
- Regulation of motor neuron differentiation in thebioRxiv : the preprint server for biology · 2025Article
- Synergistic and independent roles for Nodal and FGF in zebrafish cardiac progenitor cell migration and asymmetric heart morphogenesis.Development (Cambridge, England) · 2025Article
- Neuron-specific Agrin splicing by Nova RNA-binding proteins regulates conserved neuromuscular junction development in chordates.PLoS biology · 2025Article
- A conserved RNA switch for acetylcholine receptor clustering at neuromuscular junctions in chordates.bioRxiv : the preprint server for biology · 2024Article
- Development and circuitry of the tunicate larval Motor Ganglion, a putative hindbrain/spinal cord homolog.Journal of experimental zoology. Part B, Molecular and developmental evolution · 2024Review
- New developments in the biology of fibroblast growth factors.WIREs mechanisms of disease · 2022Review
- A single motor neuron determines the rhythm of early motor behavior inScience advances · 2021Article
- Neuromesodermal Lineage Contribution to CNS Development in Invertebrate and Vertebrate Chordates.Genes · 2021Review
- Gene Editing in the Ascidian Phallusia mammillata and Tail Nerve Cord Formation.Methods in molecular biology (Clifton, N.J.) · 2021Article
- Effector gene expression underlying neuron subtype-specific traits in the Motor Ganglion of Ciona.Developmental biology · 2020Article
- Regulation of Neurogenesis by FGF Signaling and Neurogenin in the Invertebrate ChordateFrontiers in cell and developmental biology · 2020Article
- Differential Expression of a Classic Cadherin Directs Tissue-Level Contractile Asymmetry during Neural Tube Closure.Developmental cell · 2019Article
- Single-cell transcriptome profiling of the Ciona larval brain.Developmental biology · 2019Article
- Review
- Neurogenesis in the sea urchin embryo is initiated uniquely in three domains.Development (Cambridge, England) · 2018Article
- Dynamic interplay of cell fate, polarity and force generation in ascidian embryos.Current opinion in genetics & development · 2018Review
- Developmental system drift in motor ganglion patterning between distantly related tunicates.EvoDevo · 2018Article
- Transgenic Techniques for Investigating Cell Biology During Development.Advances in experimental medicine and biology · 2018Review
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Authors and funding
2 authors at 1 institution in 1 country.
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Abstract
Formation of the vertebrate neural tube represents one of the premier examples of morphogenesis in animal development. Here, we investigate this process in the simple chordate Ciona intestinalis Previous studies have implicated Nodal and FGF signals in the specification of lateral and ventral neural progenitors. We show that these signals also control the detailed cellular behaviors underlying morphogenesis of the neural tube. Live-imaging experiments show that FGF controls the intercalary movements of ventral neural progenitors, whereas Nodal is essential for the characteristic stacking behavior of lateral cells. Ectopic activation of FGF signaling is sufficient to induce intercalary behaviors in cells that have not received Nodal. In the absence of FGF and Nodal, neural progenitors exhibit a default behavior of sequential cell divisions, and fail to undergo the intercalary and stacking behaviors essential for normal morphogenesis. Thus, cell specification events occurring prior to completion of gastrulation coordinate the morphogenetic movements underlying the organization of the neural tube.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.