ArticleArchives of disease in childhood. Fetal and neonatal edition2017
Effect of body position and ventilation on umbilical artery and venous blood flows during delayed umbilical cord clamping in preterm lambs.
Article in Archives of disease in childhood. Fetal and neonatal edition, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.
- Effect of timing of umbilical cord clamping and other strategies to influence placental transfusion at preterm birth on maternal and infant outcomes.The Cochrane database of systematic reviews · 2019Pooled it
- Deferred cord clamping in twin pregnancies: benefit, risk, or missed opportunity? A narrative review.Resuscitation plus · 2026Review
- Transitional circulation and hemodynamic monitoring in newborn infants.Pediatric research · 2024Review
- Physiological-Based Cord Clamping: When the Baby Is Ready for Clamping.Neonatology · 2024Review
- Randomized Trial of 21% versus 100% Oxygen during Chest Compressions Followed by Gradual versus Abrupt Oxygen Titration after Return of Spontaneous Circulation in Neonatal Lambs.Children (Basel, Switzerland) · 2023Article
- Comparing two different placental transfusion strategies for very preterm infants at birth: a matched-pairs study.Annals of medicine · 2023Article
- Effect of breathing on venous return during delayed cord clamping: an observational study.Archives of disease in childhood. Fetal and neonatal edition · 2022Observational
- Effect of maternal oxytocin on umbilical venous and arterial blood flows during physiological-based cord clamping in preterm lambs.PloS one · 2021Article
- [Newborn resuscitation and support of transition of infants at birth].Notfall & rettungsmedizin · 2021Review
- The Association Between Placental Residual Blood Volume and Two Placental Transfusion Methods After Delivery at Term.Frontiers in pediatrics · 2021Article
- A Case of Severe Infant-to-Placenta Hemorrhage in Association with Prolonged Delayed Cord Clamping.The American journal of case reports · 2020Article
- Effect of spontaneous breathing on umbilical venous blood flow and placental transfusion during delayed cord clamping in preterm lambs.Archives of disease in childhood. Fetal and neonatal edition · 2020Article
- Clinical aspects of incorporating cord clamping into stabilisation of preterm infants.Archives of disease in childhood. Fetal and neonatal edition · 2018Review
- Ventilation Prior to Umbilical Cord Clamping Improves Cardiovascular Stability and Oxygenation in Preterm Lambs After Exposure to Intrauterine Inflammation.Frontiers in pediatrics · 2018Article
Corrections and comments
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Authors and funding
10 authors at 7 institutions in 2 countries.
Funding
Abstract
objectiveWhile delayed umbilical cord clamping (UCC) is thought to facilitate placental to infant blood transfusion, the physiological factors regulating flow in the umbilical arteries and veins during delayed UCC is unknown. We investigated the effects of gravity, by changing fetal height relative to the placenta, and ventilation on umbilical blood flows and the cardiovascular transition during delayed UCC at birth.
methodsCatheters and flow probes were implanted into preterm lambs (128 days) prior to delivery to measure pulmonary, carotid, umbilical artery (UaBF) and umbilical venous (UvBF) blood flows. Lambs were placed either 10 cm below or 10 cm above the ewe. Ventilation commenced 2-3 min before UCC and continued for 30 min after UCC.
resultsGravity reduced umbilical and cerebral flows when lambs were placed below the midline, but the reduction in UaBF and UvBF was similar. Ventilation during delayed UCC reduced UvBF and UaBF by similar amounts, irrespective of the lamb's position, such that flows into and out of the placenta remained balanced. The effects of ventilation on umbilical flows were much greater than the effects of gravity, but no net placental to lamb blood transfusion could be detected under any condition. Cardiovascular parameters, cerebral oxygen kinetics and final blood volumes were similar in both groups 5 min after UCC.
conclusionsGravity caused small transient effects on umbilical and cerebral flow, but given changes were similar in umbilical arteries and veins, no net placental transfusion was detected. Ventilation during delayed UCC has a markedly greater influence on cardiovascular function in the newborn.
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Registered trials
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