ArticleScientific reports2016
Functional roles of Arabidopsis CKRC2/YUCCA8 gene and the involvement of PIF4 in the regulation of auxin biosynthesis by cytokinin.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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28 citing papers in PubMed, 46 citations in OpenAlex.
- Short-day photoperiod enhances graft success by increasing auxin accumulation.Plant signaling & behavior · 2026Article
- Evolutionary origin of a new gene drives root growth in one desert poplar.The New phytologist · 2026Article
- The Role of Endogenous Hormones in Regulating Early Development of Stone Fruit.Plants (Basel, Switzerland) · 2026Review
- The IAOx-Dependent IAA Biosynthesis Pathway: Acquired Insights, Paradigm Shifts, and Unresolved Questions.Plants (Basel, Switzerland) · 2026Review
- Auxin Biosynthesis, Transport, Signaling, and Its Roles in Plant Leaf Morphogenesis.Plants (Basel, Switzerland) · 2025Review
- The HD-ZIP II Transcription Factors HAT3 and ATHB4 Fine-Tune Auxin and Cytokinin Pathways During Flower Development.Plants (Basel, Switzerland) · 2025Article
- Article
- Plant Growth Regulation in Cell and Tissue Culture In Vitro.Plants (Basel, Switzerland) · 2024Review
- Precise Regulation of the TAA1/TAR-YUCCA Auxin Biosynthesis Pathway in Plants.International journal of molecular sciences · 2023Review
- Optimization of the growth conditions through response surface methodology and metabolomics for maximizing the auxin production byFrontiers in microbiology · 2023Article
- Mapping quantitative trait loci and predicting candidate genes forFrontiers in genetics · 2023Article
- Significance of NatB-mediated N-terminal acetylation of auxin biosynthetic enzymes in maintaining auxin homeostasis in Arabidopsis thaliana.Communications biology · 2022Article
- TANDEM ZINC-FINGER/PLUS3 regulates phytochrome B abundance and signaling to fine-tune hypocotyl growth.The Plant cell · 2022Article
- Auxin-Cytokinin Cross Talk in Somatic Embryogenesis ofPlants (Basel, Switzerland) · 2022Article
- The Photoperiod Stress Response inInternational journal of molecular sciences · 2022Article
- Auxin/Cytokinin Antagonistic Control of the Shoot/Root Growth Ratio and Its Relevance for Adaptation to Drought and Nutrient Deficiency Stresses.International journal of molecular sciences · 2022Review
- MicroRNAs Are Involved in Regulating Plant Development and Stress Response through Fine-Tuning of TIR1/AFB-Dependent Auxin Signaling.International journal of molecular sciences · 2022Review
- The roles of epigenetic modifications in the regulation of auxin biosynthesis.Frontiers in plant science · 2022Review
- Adipose tissue hyaluronan production improves systemic glucose homeostasis and primes adipocytes for CL 316,243-stimulated lipolysis.Nature communications · 2021Article
- Cytokinin-Controlled Gradient Distribution of Auxin inInternational journal of molecular sciences · 2021Review
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Auxin and cytokinin (CK) are both important hormones involved in many aspects of plant growth and development. However, the details of auxin biosynthesis and the interaction between auxin and CK are still unclear. Isolation and characterization of an auxin deficient mutant cytokinin induced root curling 2 (ckrc2) in this work reveal that CKRC2 encodes a previously identified member of YUCCA (YUC) flavin monooxygenase-like proteins (YUC8). Our results show that, like other YUCs, CKRC2/YUC8 is a rate-limiting enzyme for catalyzing the conversion of indole-3-pyruvic acid (IPyA) to indole-3-acetic acid (IAA), acting downstream of CKRC1/TAA1 in the IPyA pathway. Here we show that the transcription of both CKRC1/TAA and CKRC2/YUC8 can be induced by CK and that the phytochrome-interacting factor 4 (PIF4) is required for this upregulation. Transcription of PIF4 itself is induced by CK via the AHKs-ARR1/12 signalling pathway. These results indicate that PIF4 plays an essential role in mediating the regulatory effect of CK on the transcriptions of CKRC1 and CKRC2 genes in the IPyA pathway of auxin biosynthesis.
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