ArticleInfection2017
Anti-N-methyl-D-aspartate receptor encephalitis after Herpes simplex virus-associated encephalitis: an emerging disease with diagnosis and therapeutic challenges.
Article in Infection, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 36 citations in OpenAlex.
- Clinical analysis of 73 children with anti-N-methyl-D-aspartic receptor (NMDAR) encephalitis.Translational pediatrics · 2025Article
- Ictal vomiting as an unusual presentation of herpes simplex encephalitis - Pathophysiological and therapeutic perspectives.IDCases · 2025Article
- Post-Herpetic Anti-NMDAR Encephalitis in Denmark: Current Status and Future Challenges.Biomedicines · 2024Article
- Type 2 herpes simplex virus-induced anti-N-methyl-D-aspartate receptor encephalitis responsive to immunoglobulin monotherapy.Journal of neurovirology · 2024Article
- When herpes simplex virus encephalitis meets antiviral innate immunity.Frontiers in immunology · 2023Review
- A Rare Presentation of a Complex Mixed Autoimmune Encephalitis Diagnosis: A Case Report and Literature Review.Cureus · 2022Article
- Recurrent anti-NMDAR encephalitis during pregnancy combined with two antibodies positive.Archives of women's mental health · 2021Review
- De Novo Movement Disorders and COVID-19: Exploring the Interface.Movement disorders clinical practice · 2021Review
- HSV encephalitis triggered anti-NMDAR encephalitis: a case report.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2021Review
- Anti-NMDAR Encephalitis Following Herpes Simplex Virus Encephalitis: 2 Cases From Portugal.The Neurohospitalist · 2020Article
- Two Cases of Late-Onset Anti-NMDAr Auto-Immune Encephalitis After Herpes Simplex Virus 1 Encephalitis.Frontiers in neurology · 2020Article
- The diffuse involvement of anti-N-methyl-D-aspartate receptor encephalitis in brain: a case report.BMC neurology · 2019Article
- Catatonia and the immune system: a review.The lancet. Psychiatry · 2019Review
- [Progress in immunotherapy for children with anti-N-methyl-D-aspartate receptor encephalitis].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2018Article
- Neuroimmune disorders of the central nervous system in children in the molecular era.Nature reviews. Neurology · 2018Review
- Anti-NMDA receptor encephalitis triggered by epilepsy surgery.Journal of neurology · 2018Article
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionMorbidity and mortality of Herpes simplex virus encephalitis (HSE) remain high. Relapses of neurological signs may occur after initial clinical improvement under acyclovir treatment.
methodsWe report here a case of post-HSE anti-N-methyl-d-aspartate receptor-mediated encephalitis in an adult and perform a systematic search on PubMed to identify other cases in adults.
resultsWe identified 11 previously published cases, to discuss diagnostic and therapeutic management. Symptoms in adults are often inappropriate behaviors, confusion and agitation. Diagnosis of anti-NMDA-R encephalitis after HSE is often delayed. Treatment consists in steroids, plasma exchange, and rituximab. Prognosis is often favorable.
conclusionAnti-NMDA-R antibodies should be searched in cerebrospinal fluid of patients with unexpected evolution of HSE. This emerging entity reopens the hot debate about steroids in HSE.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.