Evidence map›Paper›PMID 27826792›Full record

ArticleAmino acids2017

Monocyte behaviour and tissue transglutaminase expression during experimental autoimmune encephalomyelitis in transgenic CX3CR1

Navina L Chrobok, Alexandre Jaouen, Keith K Fenrich, John G J M Bol, Micha M M Wilhelmus, Benjamin Drukarch, Franck Debarbieux, Anne-Marie van Dam

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Amino acids, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.0field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Transglutaminases in Monocytes and Macrophages.Medical sciences (Basel, Switzerland) · 2018
    Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 3 countries.

Navina L ChrobokDepartment of Anatomy and Neurosciences, Amsterdam Neuroscience, VU University Medical Center, De Boelelaan 1118, 1081 HV, Amsterdam, The Netherlands.
Alexandre JaouenEuropean Research Center for Medical Imaging, Developmental Biology Institute of Marseille, Aix Marseille Université, Campus de la Timone, Marseille, France.
Keith K FenrichEuropean Research Center for Medical Imaging, Developmental Biology Institute of Marseille, Aix Marseille Université, Campus de la Timone, Marseille, France.
John G J M BolDepartment of Anatomy and Neurosciences, Amsterdam Neuroscience, VU University Medical Center, De Boelelaan 1118, 1081 HV, Amsterdam, The Netherlands.
Micha M M WilhelmusDepartment of Anatomy and Neurosciences, Amsterdam Neuroscience, VU University Medical Center, De Boelelaan 1118, 1081 HV, Amsterdam, The Netherlands.
Benjamin DrukarchDepartment of Anatomy and Neurosciences, Amsterdam Neuroscience, VU University Medical Center, De Boelelaan 1118, 1081 HV, Amsterdam, The Netherlands.
Franck DebarbieuxEuropean Research Center for Medical Imaging, Developmental Biology Institute of Marseille, Aix Marseille Université, Campus de la Timone, Marseille, France.
Anne-Marie van DamDepartment of Anatomy and Neurosciences, Amsterdam Neuroscience, VU University Medical Center, De Boelelaan 1118, 1081 HV, Amsterdam, The Netherlands. amw.vandam@vumc.nl.ORCID 0000-0003-4191-3941
Amsterdam Neuroscience · NLAix-Marseille Université · FRUniversity of Alberta · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Leukocyte infiltration into the central nervous system (CNS) is a key pathological feature in multiple sclerosis (MS) and the MS animal model experimental autoimmune encephalomyelitis (EAE). Recently, preventing leukocyte influx into the CNS of MS patients is the main target of MS therapies and insight into cell behaviour in the circulation is needed for further elucidation of such therapies. In this study, we aimed at in vivo visualization of monocytes in a time-dependent manner during EAE. Using intravital two-photon microscopy (IVM), we imaged CX3CR1

Indexed as

AnimalsCell AdhesionCell MovementCell TrackingCX3C Chemokine Receptor 1Disease Models, AnimalEncephalomyelitis, Autoimmune, ExperimentalGene ExpressionGreen Fluorescent ProteinsGTP-Binding ProteinsMiceMice, Inbred C57BLMice, TransgenicMicroscopy, Fluorescence, MultiphotonMolecular ImagingMonocytesCX3C Chemokine Receptor 1Cx3cr1 protein, mouseGreen Fluorescent ProteinsGTP-Binding ProteinsProtein Glutamine gamma Glutamyltransferase 2Recombinant Fusion ProteinsTransglutaminasesCell crawlingImmunohistochemistryIntravital microscopyMultiple sclerosis

Identifiers

PMID27826792
PMCPMC5332504
OpenAlexW2550061014

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.