ArticleInternational orthopaedics2017
Matrix based autologous chondrocyte implantation in children and adolescents: a match paired analysis in a follow-up over three years post-operation.
Article in International orthopaedics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 4 of them syntheses that pooled it.
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Who cites it
21 citing papers in PubMed, 4 syntheses or guidelines pooled it, 55 citations in OpenAlex.
- High Variability in Return-to-Sport Assessment After Autologous Chondrocyte Implantation of the Knee: A Systematic Review.Cartilage · 2026Pooled it
- Autologous chondrocyte implantation in the knee is effective in skeletally immature patients: a systematic review.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2023Pooled it
- Pooled it
- Articular Cartilage Repair of the Pediatric and Adolescent Knee with Regard to Minimal Clinically Important Difference: A Systematic Review.Cartilage · 2020Pooled it
- Favourable clinical outcomes and low revision rate after M-ACI in adolescents with immature cartilage compared to adult controls: Results at 10 years.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2025Article
- Highlights on Advancing Frontiers in Tissue Engineering.Tissue engineering. Part B, Reviews · 2022Review
- Differences in Clinical and Functional Outcomes Between Osteochondral Allograft Transplantation and Autologous Chondrocyte Implantation for the Treatment of Focal Articular Cartilage Defects.Orthopaedic journal of sports medicine · 2022Article
- Four cases report: Treatment of knee joint cartilage defects using autologous chondrocyte patch implantation.Frontiers in surgery · 2022Article
- Symptom Chronicity and Tobacco Use: Differences in Athletic and Nonathletic Candidates for Cartilage Surgery.Cartilage · 2021Article
- Article
- Clinical Application Status of Articular Cartilage Regeneration Techniques: Tissue-Engineered Cartilage Brings New Hope.Stem cells international · 2020Review
- Cartilage Restoration in the Adolescent Knee: a Systematic Review.Current reviews in musculoskeletal medicine · 2019Review
- A Rabbit Model of Osteochondral Regeneration Using Three-Dimensional Printed Polycaprolactone-Hydroxyapatite Scaffolds Coated with Umbilical Cord Blood Mesenchymal Stem Cells and Chondrocytes.Medical science monitor : international medical journal of experimental and clinical research · 2019Article
- Preclinical safety study of a combined therapeutic bone wound dressing for osteoarticular regeneration.Nature communications · 2019Article
- What parameters affect knee function in patients with untreated cartilage defects: baseline data from the German Cartilage Registry.International orthopaedics · 2019Article
- Matrix-Associated Autologous Chondrocyte Implantation Is an Effective Treatment at Midterm Follow-up in Adolescents and Young Adults.Orthopaedic journal of sports medicine · 2019Article
- Cartilage Defect Treatment Using High-Density Autologous Chondrocyte Implantation: Two-Year Follow-up.Cartilage · 2018Article
- Orthopaedic regenerative tissue engineering en route to the holy grail: disequilibrium between the demand and the supply in the operating room.Journal of experimental orthopaedics · 2018Review
- Pediatric Orthopaedics - from Kirschner wires to titanium.International orthopaedics · 2017Article
- Preparation of a biphase composite scaffold and its application in tissue engineering for femoral osteochondral defects in rabbits.International orthopaedics · 2017Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe aim of this study is the investigation of the clinical results after third generation autologous chondrocyte implantation in the knee in a follow-up over three years post-operation. Our primary focus is on the effects of this procedure on children and adolescent patients as there is a lack of knowledge regarding the clinical outcomes in children/adolescents in particular when compared with adults.
methodsA total of 40 patients (43 defects) <20 years with cartilage defects of the knee were treated with third generation ACI (Novocart® 3D). These defects were caused by osteochondritis dissecans (n = 13), acute trauma (<12 months) (n = 9), old trauma (>12 months) (n = 5) or unknown pathology (n = 13). The mean defect size was 5.2 cm
resultsAll patients showed significantly better clinical results compared with the pre-operative findings in the follow-up over three years. We observed significantly better results in the IKDC score and VAS during the whole postoperative follow-up in children and adolescents after six, 12, 24 and 36 months compared with the adult control group. The IKDC score improved from 46.5 preoperative to 77.5 (+31) after three years in children and adolescents. Similarly, significantly lower stress pain after six months and one, two and three years was found in this group.
conclusionThis study showed that third generation autologous chondrocyte implantation is a suitable method for the treatment of full cartilage defects in children and adolescents.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.