Observational studyPediatric nephrology (Berlin, Germany)2017
Renin-angiotensin II-aldosterone system blockers and time to renal replacement therapy in children with CKD.
Observational study in Pediatric nephrology (Berlin, Germany), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00327860 (Chronic Kidney Disease in Children Prospective Cohort Study), which is not on this map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Chronic Kidney Disease in Children Prospective Cohort Study (CKiD)
Who cites it
16 citing papers in PubMed.
- Australian Guideline for the Identification and Management of Hypertension in Children and Adolescents.Journal of paediatrics and child health · 2026Article
- Early detection of proteinuria to prevent kidney fibrosis and progression to kidney failure: lessons from the School Urine Screening Program in Japan.Pediatric nephrology (Berlin, Germany) · 2026Review
- How to delay the progression of chronic kidney disease: focusing on medications.Childhood kidney diseases · 2024Review
- The Preserving Kidney Function in Children With CKD (PRESERVE) Study: Rationale, Design, and Methods.Kidney medicine · 2023Article
- Hyperkalemia in pediatric chronic kidney disease.Pediatric nephrology (Berlin, Germany) · 2023Article
- Effect of Age on Hypertension Recognition in Children With Chronic Kidney Disease: A Report From the Chronic Kidney Disease in Children Study.Hypertension (Dallas, Tex. : 1979) · 2023Article
- Case report: Withdrawal of angiotensin-converting enzyme inhibitors in children with advanced chronic kidney disease and rapidly declining kidney function.Frontiers in pediatrics · 2023Article
- Acute kidney injury in pediatric hematopoietic cell transplantation: critical appraisal and consensus.Pediatric nephrology (Berlin, Germany) · 2022Review
- Kidney Disease Progression in Children and Young Adults With Pediatric CKD: Epidemiologic Perspectives and Clinical Applications.Seminars in nephrology · 2021Review
- Mean Arterial Pressure and Chronic Kidney Disease Progression in the CKiD Cohort.Hypertension (Dallas, Tex. : 1979) · 2021Observational
- When should we start and stop ACEi/ARB in paediatric chronic kidney disease?Pediatric nephrology (Berlin, Germany) · 2021Review
- The CKiD study: overview and summary of findings related to kidney disease progression.Pediatric nephrology (Berlin, Germany) · 2021Review
- Blood pressure in children with chronic kidney disease: lessons learned from the Chronic Kidney Disease in Children Cohort Study.Pediatric nephrology (Berlin, Germany) · 2020Review
- Albuminuria, Hypertension, and Reduced Kidney Volumes in Adolescents Born Extremely Premature.Frontiers in pediatrics · 2020Article
- Adherence to long-term use of renin-angiotensin II-aldosterone system inhibitors in children with chronic kidney disease.BMC pediatrics · 2019Article
- Time-varying coefficient of determination to quantify the explanatory power of biomarkers on longitudinal GFR among children with chronic kidney disease.Annals of epidemiology · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
backgroundClinical care decisions to treat chronic kidney disease (CKD) in a growing child must often be made without the benefit of evidence from clinical trials. We used observational data from the Chronic Kidney Disease in Children cohort to estimate the effectiveness of renin-angiotensin II-aldosterone system blockade (RAAS) to delay renal replacement therapy (RRT) in children with CKD.
methodsA total of 851 participants (median age: 11 years, median glomerular filtration rate [GFR]: 52 ml/min/1.73 m
resultsThere were 217 RRT events over a 4.1-year median follow-up. At baseline, 472 children (55 %) were prevalent RAAS users, who were more likely to be older, have a glomerular etiology, have higher urine protein, be anemic, have elevated serum phosphate and potassium, take more medications, but less likely to have elevated blood pressure, compared with non-users. RAAS use was found to reduce the risk of RRT by 21 % (hazard ratio: 0.79) to 37 % (hazard ratio: 0.63) from standard regression adjustment and MSM models, respectively.
conclusionsThese results support inferences from adult studies of a substantial benefit of RAAS use in pediatric CKD patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.