Immune surveillance of liver cancer in non-alcoholic fatty liver disease: excess lipids cause CD4 T-cells loss and promote hepatocellular carcinoma development.

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.

1. Clinicopathologic and prognostic significance of regulatory T cells in patients with hepatocellular carcinoma: a meta-analysis.Oncotarget · 2017
   Pooled it
2. Neutrophil extracellular traps: A central player in liver diseases.Hepatology communications · 2026
   Review
3. Role of miRNA signalling in the pathogenesis of MASLD.Frontiers in pharmacology · 2026
   Review
4. HIV, Viral Hepatitis, and Schistosomiasis Association with Liver Cancer: A Systematic Review.Microorganisms · 2025
   Review
5. Innovative approaches to CAR-T cell therapy: the role of lipid metabolism pathways.Journal of translational medicine · 2025
   Review
6. A new insight: crosstalk between neutrophil extracellular traps and the gut-liver axis for nonalcoholic fatty liver disease.Frontiers in immunology · 2025
   Review
7. Identification of neutrophil extracellular trap-related biomarkers in non-alcoholic fatty liver disease through machine learning and single-cell analysis.Scientific reports · 2024
   Article
8. The crosstalking immune cells network creates a collective function beyond the function of each cellular constituent during the progression of hepatocellular carcinoma.Scientific reports · 2023
   Article
9. The implication of neutrophil extracellular traps in nonalcoholic fatty liver disease.Frontiers in immunology · 2023
   Review
10. Restoration of CD4Cancers · 2022
    Article
11. Impact of regulatory T cells on the prognosis of hepatocellular carcinoma: A protocol for systematic review and meta analysis.Medicine · 2021
    Article
12. Correlation of CD3+/CD4+, and serum CK-18 fragment levels with glucose and lipid metabolism in elderly type 2 diabetes patients with nonalcoholic fatty liver disease.American journal of translational research · 2021
    Article
13. Anti-cancer efficacy of biotinylated chitosan nanoparticles in liver cancer.Oncotarget · 2017
    Article
14. Cancer of the Liver and its Relationship with Diabetes mellitus.Technology in cancer research & treatment
    Review

Corrections and comments

• Comment on
  NAFLD causes selective CD4(+) T lymphocyte loss and promotes hepatocarcinogenesis.2016

Authors and funding

2 authors at 1 institution in 1 country.

Funding

No grant is acknowledged in the PubMed record.

Abstract

PubMed holds no abstract for this paper.