ArticleFrontiers in molecular biosciences2016
Lysosomal Cathepsin A Plays a Significant Role in the Processing of Endogenous Bioactive Peptides.
Article in Frontiers in molecular biosciences, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 37 citations in OpenAlex.
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- Gene expression QTL mapping in stimulated iPSC-derived macrophages provides insights into common complex diseases.Nature communications · 2025Article
- Benzoxazole-derivatives enhance progranulin expression and reverse the aberrant lysosomal proteome caused by GRN haploinsufficiency.Nature communications · 2024Article
- Broadening Horizons: Exploring the Cathepsin Family as Therapeutic Targets for Alzheimer's Disease.Aging and disease · 2024Review
- Antioxidant Activity of Beef, Pork and Chicken Burgers before and after Cooking and after In Vitro Intestinal Digestion.Foods (Basel, Switzerland) · 2023Article
- Lung macrophages utilize unique cathepsin K-dependent phagosomal machinery to degrade intracellular collagen.Life science alliance · 2023Article
- Combining mass spectrometry and machine learning to discover bioactive peptides.Nature communications · 2022Article
- Tensile strain and altered synovial tissue metabolism in human knee osteoarthritis.Scientific reports · 2022Article
- Cathepsin a upregulation in glioma: A potential therapeutic target associated with immune infiltration.Journal of medical biochemistry · 2022Article
- In Silico Structural Analysis of Serine CarboxypeptidaseInternational journal of molecular sciences · 2022Article
- The Key Role of Lysosomal Protease Cathepsins in Viral Infections.International journal of molecular sciences · 2022Review
- The neurovascular unit in leukodystrophies: towards solving the puzzle.Fluids and barriers of the CNS · 2022Review
- Pathology of the neurovascular unit in leukodystrophies.Acta neuropathologica communications · 2021Article
- Cathepsin A contributes to left ventricular remodeling by degrading extracellular superoxide dismutase in mice.The Journal of biological chemistry · 2020Article
- Saliva proteomic patterns in patients with molar incisor hypomineralization.Scientific reports · 2020Article
- Cathepsins in the Pathophysiology of Mucopolysaccharidoses: New Perspectives for Therapy.Cells · 2020Review
- Structure Dependent Determination of Organophosphate Targets in Mammalian Tissues Using Activity-Based Protein Profiling.Chemical research in toxicology · 2020Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Lysosomal serine carboxypeptidase Cathepsin A (CTSA) is a multifunctional enzyme with distinct protective and catalytic function. CTSA present in the lysosomal multienzyme complex to facilitate the correct lysosomal routing, stability and activation of with beta-galactosidase and alpha-neuraminidase. Beside CTSA has role in inactivation of bioactive peptides including bradykinin, substances P, oxytocin, angiotensin I and endothelin-I by cleavage of 1 or 2 amino acid(s) from C-terminal ends. In this study, we aimed to elucidate the regulatory role of CTSA on bioactive peptides in knock-in mice model of
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