Evidence map›Paper›PMID 27826462›Full record

ArticlePlastic and reconstructive surgery. Global open2016

Reconstruction of Alar Nasal Cartilage Defects Using a Tissue Engineering Technique Based on a Combined Use of Autologous Chondrocyte Micrografts and Platelet-rich Plasma: Preliminary Clinical and Instrumental Evaluation.

Pietro Gentile, Maria G Scioli, Alessandra Bielli, Augusto Orlandi, Valerio Cervelli

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Plastic and reconstructive surgery. Global open, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
4.1field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Dorsal Augmentation Rhinoplasty by Cartilage Allograft.Journal of cosmetic dermatology · 2025
    Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Dominant role ofBioactive materials · 2022
    Article
  9. Article
  10. Article
  11. [Research progress of autogenous cartilage scaffold carving method in rhinoplasty].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2021
    Article
  12. Review
  13. Article
  14. Article
  15. Clinical Applications for Tissue Engineering in Rhinology.Turkish archives of otorhinolaryngology · 2019
    Review
  16. Article
  17. Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Pietro GentilePlastic and Reconstructive Surgery Department, University of Rome Tor Vergata, Rome, Italy; Plastic and Reconstructive Surgery, Catholic University, Tirana, Albania; and Institute of Anatomic Pathology, University of Rome Tor Vergata, Rome, Italy.
Maria G ScioliPlastic and Reconstructive Surgery Department, University of Rome Tor Vergata, Rome, Italy; Plastic and Reconstructive Surgery, Catholic University, Tirana, Albania; and Institute of Anatomic Pathology, University of Rome Tor Vergata, Rome, Italy.
Alessandra BielliPlastic and Reconstructive Surgery Department, University of Rome Tor Vergata, Rome, Italy; Plastic and Reconstructive Surgery, Catholic University, Tirana, Albania; and Institute of Anatomic Pathology, University of Rome Tor Vergata, Rome, Italy.
Augusto OrlandiPlastic and Reconstructive Surgery Department, University of Rome Tor Vergata, Rome, Italy; Plastic and Reconstructive Surgery, Catholic University, Tirana, Albania; and Institute of Anatomic Pathology, University of Rome Tor Vergata, Rome, Italy.
Valerio CervelliPlastic and Reconstructive Surgery Department, University of Rome Tor Vergata, Rome, Italy; Plastic and Reconstructive Surgery, Catholic University, Tirana, Albania; and Institute of Anatomic Pathology, University of Rome Tor Vergata, Rome, Italy.
University of Rome Tor Vergata · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDeveloping cartilage constructs with injectability, appropriate matrix composition, and persistent cartilaginous phenotype remains an enduring challenge in cartilage repair. The combined use of autologous chondrocyte micrografts and platelet-rich plasma (PRP) is an alternative that opens a new era in this field.

methodsAt the Department of Plastic and Reconstructive Surgery, University of Rome Tor Vergata, Italy, 11 patients underwent nasal alar reconstruction with chondrocyte micrografts gently poured onto PRP in solid form. A computed tomographic scan control was performed after 12 months. Pearson's Chi-square test was used to investigate difference in cartilage density between native and newly formed cartilages.

resultsThe constructs of chondrocyte micrografts-PRP that were subcutaneously injected resulted in a persistent cartilage tissue with appropriate morphology, adequate central nutritional perfusion without central necrosis or ossification, and further augmented nasal dorsum without obvious contraction and deformation.

conclusionThis report demonstrated that chondrocyte micrografts derived from nasal septum poured onto PRP in solid form are useful for cartilage regeneration in patients with external nasal valve collapse.

Identifiers

PMID27826462
PMCPMC5096517
OpenAlexW2545661246

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.