Evidence map›Paper›PMID 27826286›Full record

ArticleFrontiers in microbiology2016

Transcriptomic Biomarkers for Tuberculosis: Evaluation of

Leonardo S de Araujo, Lea A I Vaas, Marcelo Ribeiro-Alves, Robert Geffers, Fernanda C Q Mello, Alexandre S de Almeida, Adriana da S R Moreira, Afrânio L Kritski, José R Lapa E Silva, Milton O Moraes and 2 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in microbiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 4 pooled it
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 4 syntheses or guidelines pooled it, 50 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. The Impact of Vitamin A Deficiency on Tuberculosis Progression.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2022
    Trial
  6. Article
  7. Monocyte-Amplified Transcriptional Signatures of Human Diseases.bioRxiv : the preprint server for biology · 2026
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. The Biological and Clinical Aspects of a Latent Tuberculosis Infection.Tropical medicine and infectious disease · 2022
    Review
  16. Increased UBE2L6 regulated by type 1 interferon as potential marker in TB.Journal of cellular and molecular medicine · 2021
    Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 2 countries.

Leonardo S de AraujoLaboratório de Microbiologia Celular, Fundação Oswaldo Cruz, Instituto Oswaldo Cruz Rio de Janeiro, Brazil.
Lea A I VaasTWINCORE, Center for Experimental and Clinical Infection Research Hannover, Germany.
Marcelo Ribeiro-AlvesLaboratório de Pesquisa Clínica em DST-AIDS, Fundação Oswaldo Cruz, Instituto de Pesquisa Clínica Evandro Chagas Rio de Janeiro, Brazil.
Robert GeffersHelmholtz Centre for Infection Research Braunschweig, Germany.
Fernanda C Q MelloThoracic Diseases Institute, Federal University of Rio de Janeiro Rio de Janeiro, Brazil.
Alexandre S de AlmeidaLaboratório de Hanseníase, Fundação Oswaldo Cruz, Instituto Oswaldo Cruz Rio de Janeiro, Brazil.
Adriana da S R MoreiraThoracic Diseases Institute, Federal University of Rio de Janeiro Rio de Janeiro, Brazil.
Afrânio L KritskiThoracic Diseases Institute, Federal University of Rio de Janeiro Rio de Janeiro, Brazil.
José R Lapa E SilvaThoracic Diseases Institute, Federal University of Rio de Janeiro Rio de Janeiro, Brazil.
Milton O MoraesLaboratório de Hanseníase, Fundação Oswaldo Cruz, Instituto Oswaldo Cruz Rio de Janeiro, Brazil.
Frank PesslerTWINCORE, Center for Experimental and Clinical Infection ResearchHannover, Germany; Helmholtz Centre for Infection ResearchBraunschweig, Germany.
Maria H F SaadLaboratório de Microbiologia Celular, Fundação Oswaldo Cruz, Instituto Oswaldo Cruz Rio de Janeiro, Brazil.
Fundação Oswaldo Cruz · BRUniversidade Federal do Rio de Janeiro · BRCenter for Experimental and Clinical Infection Research · DEHelmholtz Centre for Infection Research · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lately, much effort has been made to find mRNA biomarkers for tuberculosis (TB) disease/infection with microarray-based approaches. In a pilot investigation, through RNA sequencing technology, we observed a prominent modulation of

Indexed as

biomarkersLTBImessenger RNAM. tuberculosistuberculosis

Identifiers

PMID27826286
PMCPMC5078140
OpenAlexW2536047199

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.