ArticleFrontiers in physiology2016
Immature Spinal Locomotor Output in Children with Cerebral Palsy.
Article in Frontiers in physiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 72 papers, 1 of them a synthesis that pooled it.
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Who cites it
72 citing papers in PubMed, 1 synthesis or guideline pooled it, 121 citations in OpenAlex.
- Muscle Synergies During Walking in Children With Cerebral Palsy: A Systematic Review.Frontiers in physiology · 2020Pooled it
- Neuromuscular organisation and robustness of postural control in the presence of perturbations.Scientific reports · 2019Trial
- Influence of surgical intervention on pre- and post-surgery patient specific muscle synergies in children with cerebral palsy.Experimental brain research · 2026Article
- Real-time approach to evaluate spinal cord topography of motor pool activation during gait.Frontiers in bioengineering and biotechnology · 2026Article
- Neuromuscular control strategies during the Tai Chi heel-kick movement across different levels of motor experience.Frontiers in physiology · 2026Article
- The role of independent walking in the maturation of the spinal locomotor output in children with cerebral palsy.Frontiers in physiology · 2026Article
- Joint Kinematics and Muscle Activity in Response to Prolonged Standing: Analysis of Standing and Subsequent Gait.Annals of biomedical engineering · 2025Article
- Research on the Impact of Shot Selection on Neuromuscular Control Strategies During Basketball Shooting.Sensors (Basel, Switzerland) · 2025Article
- Exploring the cortical involvement in sensorimotor integration during early stages of independent walking.Experimental brain research · 2025Article
- The effects of weight-bearing manipulations on gait and its underlying neural control mechanisms in toe walking children.Frontiers in human neuroscience · 2025Article
- The impact of transcranial direct current stimulation on the neuro-muscular control strategies of penalty kicks in soccer players.Frontiers in sports and active living · 2025Article
- Kinematic-Muscular Synergies Describe Human Locomotion with a Set of Functional Synergies.Biomimetics (Basel, Switzerland) · 2024Article
- Article
- Spatiotemporal modulation of a common set of muscle synergies during unpredictable and predictable gait perturbations in older adults.The Journal of experimental biology · 2024Article
- Abnormal interlimb coordination of motor developmental delay during infant crawling based on kinematic synergy analysis.Biomedical engineering online · 2024Article
- Motor patterns of patients with spinal muscular atrophy suggestive of sensory and corticospinal contributions to the development of locomotor muscle synergies.Journal of neurophysiology · 2024Article
- Muscle synergies inherent in simulated hypogravity running reveal flexible but not unconstrained locomotor control.Scientific reports · 2024Article
- Spinal maps of motoneuron activity during human locomotion: neuromechanical considerations.Frontiers in physiology · 2024Review
- Evaluation of EMG patterns in children during assisted walking in the exoskeleton.Frontiers in neuroscience · 2024Article
- A Study of Racket Weight Adaptation in Advanced and Beginner Badminton Players.Applied bionics and biomechanics · 2024Article
12 more citing papers are in PubMed but not listed here.
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Detailed descriptions of gait impairments have been reported in cerebral palsy (CP), but it is still unclear how maturation of the spinal motoneuron output is affected. Spatiotemporal alpha-motoneuron activation during walking can be assessed by mapping the electromyographic activity profiles from several, simultaneously recorded muscles onto the anatomical rostrocaudal location of the motoneuron pools in the spinal cord, and by means of factor analysis of the muscle activity profiles. Here, we analyzed gait kinematics and EMG activity of 11 pairs of bilateral muscles with lumbosacral innervation in 35 children with CP (19 diplegic, 16 hemiplegic, 2-12 years) and 33 typically developing (TD) children (1-12 years). TD children showed a progressive reduction of EMG burst durations and a gradual reorganization of the spatiotemporal motoneuron output with increasing age. By contrast, children with CP showed very limited age-related changes of EMG durations and motoneuron output, as well as of limb intersegmental coordination and foot trajectory control (on both sides for diplegic children and the affected side for hemiplegic children). Factorization of the EMG signals revealed a comparable structure of the motor output in children with CP and TD children, but significantly wider temporal activation patterns in children with CP, resembling the patterns of much younger TD infants. A similar picture emerged when considering the spatiotemporal maps of alpha-motoneuron activation. Overall, the results are consistent with the idea that early injuries to developing motor regions of the brain substantially affect the maturation of the spinal locomotor output and consequently the future locomotor behavior.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.