ArticleFrontiers in human neuroscience2016
The Parkinsonian Subthalamic Network: Measures of Power, Linear, and Non-linear Synchronization and their Relationship to L-DOPA Treatment and OFF State Motor Severity.
Article in Frontiers in human neuroscience, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Using Magnetoencephalography to Advance the Science of Parkinson Disease: A Systematic Review.Brain and behavior · 2025Pooled it
- Local field potential biomarkers for adaptive deep brain stimulation in Parkinson's disease: A scoping review.Surgical neurology international · 2026Review
- Criticality and increased intrinsic neural timescales in stroke.NPJ systems biology and applications · 2025Article
- Beyond beta rhythms: subthalamic aperiodic broadband power scales with Parkinson's disease severity-a cross-sectional multicentre study.EBioMedicine · 2025Article
- Subthalamic Activity Is Associated With Proactive Inhibition in Parkinson's Disease Patients.The European journal of neuroscience · 2025Article
- Investigating structural and functional aspects of the brain's criticality in stroke.Scientific reports · 2023Article
- Subthalamic high-beta oscillation informs the outcome of deep brain stimulation in patients with Parkinson's disease.Frontiers in human neuroscience · 2022Article
- Differential dopaminergic modulation of spontaneous cortico-subthalamic activity in Parkinson's disease.eLife · 2021Article
- Parkinson's disease uncovers an underlying sensitivity of subthalamic nucleus neurons to beta-frequency cortical input in vivo.Neurobiology of disease · 2020Article
- Identification of nonlinear features in cortical and subcortical signals of Parkinson's Disease patients via a novel efficient measure.NeuroImage · 2020Article
- A biophysical model of striatal microcircuits suggests gamma and beta oscillations interleaved at delta/theta frequencies mediate periodicity in motor control.PLoS computational biology · 2020Article
- Why Brain Criticality Is Clinically Relevant: A Scoping Review.Frontiers in neural circuits · 2020Article
- L-dopa treatment increases oscillatory power in the motor cortex of Parkinson's disease patients.NeuroImage. Clinical · 2020Article
- Freezing of gait in Parkinson's disease reflects a sudden derangement of locomotor network dynamics.Brain : a journal of neurology · 2019Article
- EEG functional connectivity metrics wPLI and wSMI account for distinct types of brain functional interactions.Scientific reports · 2019Article
- Propagation of beta/gamma rhythms in the cortico-basal ganglia circuits of the parkinsonian rat.Journal of neurophysiology · 2018Article
- Criticality is Associated with Future Psychotherapy Response in Patients with Post-Traumatic Stress Disorder-A Pilot Study.Chronic stress (Thousand Oaks, Calif.)Article
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10 authors.
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Abstract
In this paper we investigated the dopaminergic modulation of neuronal interactions occurring in the subthalamic nucleus (STN) during Parkinson's disease (PD). We utilized linear measures of local and long range synchrony such as power and coherence, as well as Detrended Fluctuation Analysis for Phase Synchrony (DFA-PS)- a recently developed non-linear method that computes the extent of long tailed autocorrelations present in the phase interactions between two coupled signals. Through analysis of local field potentials (LFPs) taken from the STN we seek to determine changes in the neurodynamics that may underpin the pathophysiology of PD in a group of 12 patients who had undergone surgery for deep brain stimulation. We demonstrate up modulation of alpha-theta (5-12 Hz) band power in response to L-DOPA treatment, whilst low beta band power (15-20 Hz) band-power is suppressed. We also find evidence for significant local connectivity within the region surrounding STN although there was evidence for its modulation via administration of L-DOPA. Further to this we present evidence for a positive correlation between the phase ordering of bilateral STN interactions and the severity of bradykinetic and rigidity symptoms in PD. Although, the ability of non-linear measures to predict clinical state did not exceed standard measures such as beta power, these measures may help identify the connections which play a role in pathological dynamics.
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