Evidence map›Paper›PMID 27826186›Full record

ArticlePatient preference and adherence2016

Association between addressing antiseizure drug side effects and patient-reported medication adherence in epilepsy.

Lidia M V R Moura, Thiago S Carneiro, Andrew J Cole, John Hsu, Barbara G Vickrey, Daniel B Hoch

Open access · goldAbstract read
In one paragraph

Article in Patient preference and adherence, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. The Role of Clinical Pharmacist in Pediatrics' Adherence to Antiepileptic Drugs.The Journal of pharmacy technology : jPT : official publication of the Association of Pharmacy Technicians · 2022
    Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Lidia M V R MouraDepartment of Neurology.
Thiago S CarneiroDepartment of Neurology.
Andrew J ColeDepartment of Neurology.
John HsuMongan Institute for Health Policy, Department of Medicine, Massachusetts General Hospital; Department of Health Care Policy, Harvard Medical School, Boston, MA.
Barbara G VickreyDepartment of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Daniel B HochDepartment of Neurology.
Harvard University · USIcahn School of Medicine at Mount Sinai · US

Funding

Tradeoffs in the Design of Public Long-Term Care BenefitsP01AG032952 · NIA · HARVARD MEDICAL SCHOOL · PI John Michael McWilliams · 2009 to 2026
$39.0M
Natural Experiment of Value-Based Incentives for Preventive ServicesR01HD075121 · NICHD · MASSACHUSETTS GENERAL HOSPITAL · PI HSU, JOHN · 2012 to 2016
$3.3M
Fixed Dose Intervention Trial of New England Enhancing Survival in SMI PatientsR01MH104560 · NIMH · MCLEAN HOSPITAL · PI HSU, JOHN, ONGUR, DOST · 2014 to 2017
$3.0M
Screening for Free: A Value-Based Insurance Design Natural ExperimentR01CA164023 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI HSU, JOHN · 2012 to 2015
$2.4M
NCI NIH HHS R01 CA164023NIA NIH HHS P01 AG032952NICHD NIH HHS R01 HD075121NIMH NIH HHS R01 MH104560
6 · The paper itself

Abstract

BACKGROUND AND

aimAdherence to treatment is a critical component of epilepsy management. This study examines whether addressing antiepileptic drug (AED) side effects at every visit is associated with increased patient-reported medication adherence. PATIENTS AND

methodsThis study identified 243 adults with epilepsy who were seen at two academic outpatient neurology settings and had at least two visits over a 3-year period. Demographic and clinical characteristics were abstracted. Evidence that AED side effects were addressed was measured through 1) phone interview (patient-reported) and 2) medical records abstraction (physician-documented). Medication adherence was assessed using the validated Morisky Medication Adherence Scale-4. Complete adherence was determined as answering "no" to all questions.

resultsSixty-two (25%) patients completed the interviews. Participants and nonparticipants were comparable with respect to demographic and clinical characteristics; however, a smaller proportion of participants had a history of drug-resistant epilepsy than nonparticipants (17.7% vs 30.9%, DISCUSSION AND

conclusionAmong patients with epilepsy, addressing medication side effects at every visit does not appear to increase patient-reported medication adherence.

Indexed as

antiepileptic drug side effectsepilepsymedication adherence

Identifiers

PMID27826186
PMCPMC5096772
OpenAlexW2544292716

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.