ArticleClinical ophthalmology (Auckland, N.Z.)2016
Preliminary analysis of the relationship between serum lutein and zeaxanthin levels and macular pigment optical density.
Article in Clinical ophthalmology (Auckland, N.Z.), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- Trial
- The effects of lutein, zeaxanthin and anthocyanins supplementation on visual function and vision protection in healthy school-aged children: a single-center prospective randomized controlled study.Journal of clinical biochemistry and nutrition · 2026Article
- Assessing the role of macular pigment optical volume in non-neovascular age-related macular degeneration: associations with rod-mediated dark adaptation and disease progression.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026Observational
- Clinical management of eye diseases: carotenoids and their nanoformulations as choice of therapeutics.Naunyn-Schmiedeberg's archives of pharmacology · 2025Review
- Lutein and Zeaxanthin Distribution in the Healthy Macula and Its Association with Various Demographic Factors Examined in Pseudophakic Eyes.Antioxidants (Basel, Switzerland) · 2021Article
- Dietary Antioxidants in Age-Related Macular Degeneration and Glaucoma.Antioxidants (Basel, Switzerland) · 2021Review
- A Mechanistic Review of β-Carotene, Lutein, and Zeaxanthin in Eye Health and Disease.Antioxidants (Basel, Switzerland) · 2020Review
- Macular Pigment Optical Density in the Korean Population: a Cross Sectional Study.Journal of Korean medical science · 2020Article
- Standardizing the Assessment of Macular Pigment Using a Dual-Wavelength Autofluorescence Technique.Translational vision science & technology · 2019Article
- The Effect of Lutein on Eye and Extra-Eye Health.Nutrients · 2018Review
- Correlations Between Macular, Skin, and Serum Carotenoids.Investigative ophthalmology & visual science · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo assess the relationship between combined serum lutein and zeaxanthin (L+Z) concentration and macular pigment optical density (MPOD), and to investigate the effect of L+Z+docosahexaenoic acid (DHA) dietary supplementation on the spatial distribution of MPOD.
methodsTwenty healthy fellow eyes with unilateral wet age-related macular degeneration or chronic central serous chorioretinopathy were included. All participants received a dietary supplement for 6 months that contained 20 mg L, 1 mg Z, and 200 mg DHA. The best-corrected visual acuity and contrast sensitivity (CS) were measured at baseline and at 1, 3, and 6 months. Serum L+Z concentrations were measured at baseline and at 3 months. MPOD was calculated at each time point using fundus autofluorescent images.
resultsSerum L+Z concentration was correlated with MPOD at 1°-2° eccentricity at baseline (
conclusionJuxtafoveal MPOD was associated with serum L+Z concentration. Foveal MPOD was increased by L+Z+DHA dietary supplementation.
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Registered trials
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