Evidence map›Paper›PMID 27826102›Full record

ArticleNeuroscience2017

The TrkA receptor mediates experimental thermal hyperalgesia produced by nerve growth factor: Modulation by the p75 neurotrophin receptor.

Alla Khodorova, Grant D Nicol, Gary Strichartz

Abstract read
In one paragraph

Article in Neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
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  5. Article
  6. Article
  7. Review
  8. Review
  9. Article
  10. Article
  11. Review
  12. Review
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  15. Review
  16. Role of Nerve Growth Factor in Orofacial Pain.Journal of pain research · 2020
    Review
  17. Article
  18. Swedish Nerve Growth Factor Mutation (NGFThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2018
    Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Alla KhodorovaPain Research Center, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham & Women's Hospital, Harvard Medical School, Boston, MA, USA.
Grant D NicolDepartment of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Gary StrichartzPain Research Center, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham & Women's Hospital, Harvard Medical School, Boston, MA, USA. Electronic address: gstrichartz@partners.org.
Brigham and Women's Hospital · USIndiana University School of Medicine

Funding

Endothelin Mechanisms in Metastic Prostate Cancer PainR01CA080153 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI STRICHARTZ, GARY R · 1999 to 2014
$5.5M
The role of atypical PKCs in sensitization of sensory neurons by NGFR01NS078173 · NINDS · INDIANA UNIVERSITY INDIANAPOLIS · PI NICOL, GRANT D · 2012 to 2015
$2.0M
Endothelin mechanisms in metastic prostate cancer painR56CA080153 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI STRICHARTZ, GARY R · 2009 to 2009
$378k
NCI NIH HHS R01 CA080153NCI NIH HHS R56 CA080153NINDS NIH HHS R01 NS078173
6 · The paper itself

Abstract

The p75 neurotrophin receptor (p75

Indexed as

AnalgesicsAniline CompoundsAnimalsAntibodiesBenzylidene CompoundsCarbazolesDisease Models, AnimalEnzyme InhibitorsHot TemperatureHyperalgesiaIndole AlkaloidsMaleNerve Growth FactorNerve Tissue ProteinsProtein Kinase CRats, Sprague-DawleyAnalgesicsAniline CompoundsAntibodiesBenzylidene CompoundsCarbazolesEnzyme InhibitorsGW 4869Indole AlkaloidsN-acetylsphingosineNerve Growth FactorNerve Tissue ProteinsNgfr protein, ratProtein Kinase CReceptors, Growth FactorReceptors, Nerve Growth FactorReceptor, trkASphingosinestaurosporine aglyconeTrpv1 protein, ratTRPV Cation Channelsatypical PKChypersensitivityneurotrophinpainTRPV1

Identifiers

PMID27826102
PMCPMC5154773
OpenAlexW2546808469

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.