ArticleNeuroImage2017
Functional circuit mapping of striatal output nuclei using simultaneous deep brain stimulation and fMRI.
Article in NeuroImage, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 38 citations in OpenAlex.
- Modulatory effects of acupuncture on raphe nucleus-related brain circuits in patients with chronic neck pain: A randomized neuroimaging trial.CNS neuroscience & therapeutics · 2024Trial
- MRI-compatible soft fiber bioelectronics for multimodal assessment of electrical neural stimulation on whole-brain activation.National science review · 2026Article
- Whole Brain Monosynaptic Input of Distinct Neurons in the Globus Pallidus Externa.CNS neuroscience & therapeutics · 2025Article
- Article
- Neuromodulation in Small Animal fMRI.Journal of magnetic resonance imaging : JMRI · 2025Review
- Distinct neurochemical influences on fMRI response polarity in the striatum.Nature communications · 2024Article
- Article
- Putative neurochemical and cell type contributions to hemodynamic activity in the rodent caudate putamen.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2023Review
- Optogenetic stimulation of anterior insular cortex neurons in male rats reveals causal mechanisms underlying suppression of the default mode network by the salience network.Nature communications · 2023Article
- Mapping whole brain effects of infrared neural stimulation with positron emission tomography.Imaging neuroscience (Cambridge, Mass.) · 2023Article
- Role of deep brain stimulation (DBS) in addiction disorders.Surgical neurology international · 2023Review
- Combining magnetic resonance imaging with readout and/or perturbation of neural activity in animal models: Advantages and pitfalls.Frontiers in neuroscience · 2022Review
- An isotropic EPI database and analytical pipelines for rat brain resting-state fMRI.NeuroImage · 2021Article
- One-pot synthesis of carboxymethyl-dextran coated iron oxide nanoparticles (CION) for preclinical fMRI and MRA applications.NeuroImage · 2021Article
- Imaging the response to deep brain stimulation in rodent using functional ultrasound.Physics in medicine and biology · 2021Article
- High-Frequency Deep Brain Stimulation of the Substantia Nigra Pars Reticulata Facilitates Extinction and Prevents Reinstatement of Methamphetamine-Induced Conditioned Place Preference.Frontiers in pharmacology · 2021Article
- Article
- Automatic Skull Stripping of Rat and Mouse Brain MRI Data Using U-Net.Frontiers in neuroscience · 2020Article
- Mapping stress networks using functional magnetic resonance imaging in awake animals.Neurobiology of stress · 2018Review
- A guide to using functional magnetic resonance imaging to study Alzheimer's disease in animal models.Disease models & mechanisms · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
Abstract
The substantia nigra pars reticulata (SNr) and external globus pallidus (GPe) constitute the two major output targets of the rodent striatum. Both the SNr and GPe converge upon thalamic relay nuclei (directly or indirectly, respectively), and are traditionally modeled as functionally antagonistic relay inputs. However, recent anatomical and functional studies have identified unanticipated circuit connectivity in both the SNr and GPe, demonstrating their potential as far more than relay nuclei. In the present study, we employed simultaneous deep brain stimulation and functional magnetic resonance imaging (DBS-fMRI) with cerebral blood volume (CBV) measurements to functionally and unbiasedly map the circuit- and network level connectivity of the SNr and GPe. Sprague-Dawley rats were implanted with a custom-made MR-compatible stimulating electrode in the right SNr (n=6) or GPe (n=7). SNr- and GPe-DBS, conducted across a wide range of stimulation frequencies, revealed a number of surprising evoked responses, including unexpected CBV decreases within the striatum during DBS at either target, as well as GPe-DBS-evoked positive modulation of frontal cortex. Functional connectivity MRI revealed global modulation of neural networks during DBS at either target, sensitive to stimulation frequency and readily reversed following cessation of stimulation. This work thus contributes to a growing literature demonstrating extensive and unanticipated functional connectivity among basal ganglia nuclei.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.