Evidence map›Paper›PMID 27825764›Full record

ArticleBioorganic & medicinal chemistry letters2016

Synthesis of novel Ral inhibitors: An in vitro and in vivo study.

Chao Yan, Dan Theodorescu, Bettina Miller, Amit Kumar, Vijay Kumar, David Ross, Michael F Wempe

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioorganic & medicinal chemistry letters, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Synthesis of 2Beilstein journal of organic chemistry · 2019
    Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Chao YanDepartment of Pharmacology, University of Colorado, Aurora, CO 80045, USA; Department of Surgery, University of Colorado, Aurora, CO 80045, USA.
Dan TheodorescuDepartment of Pharmacology, University of Colorado, Aurora, CO 80045, USA; Department of Surgery, University of Colorado, Aurora, CO 80045, USA; University of Colorado Comprehensive Cancer Center, Aurora, CO 80045, USA.
Bettina MillerDepartment of Pharmaceutical Sciences, University of Colorado, Aurora, CO 80045, USA.
Amit KumarDepartment of Pharmaceutical Sciences, University of Colorado, Aurora, CO 80045, USA.
Vijay KumarDepartment of Pharmaceutical Sciences, University of Colorado, Aurora, CO 80045, USA.
David RossDepartment of Pharmaceutical Sciences, University of Colorado, Aurora, CO 80045, USA.
Michael F WempeDepartment of Pharmaceutical Sciences, University of Colorado, Aurora, CO 80045, USA. Electronic address: michael.wempe@ucdenver.edu.

Funding

Colorado Clinical and Translational Sciences InstituteUL1TR001082 · NCATS · UNIVERSITY OF COLORADO DENVER · PI SOKOL, RONALD J. · 2013 to 2017
$48.0M
Targeting Ral GTPases in Bladder CancerP50CA091846 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI DINNEY, COLIN P.N., MCCONKEY, DAVID J. · 2001 to 2018
$37.4M
Regulation and Targeting of CD24 in Bladder CancerR01CA075115 · NCI · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI THEODORESCU, DAN · 2003 to 2024
$7.0M
NCATS NIH HHS UL1 TR001082NCI NIH HHS P50 CA091846NCI NIH HHS R01 CA075115
6 · The paper itself

Abstract

Chemical synthesis was performed to produce a series of 6-amino-1,3-disubstituted-4-phenyl-1,4-dihydro pyrano[2,3-c]pyrazole-5-carbonitrile compounds (14-57) which were characterized by

Indexed as

AnimalsAntineoplastic AgentsCell Line, TumorCell ProliferationDrug DiscoveryHumansLungLung NeoplasmsMiceNitrilesPyrazolesral GTP-Binding ProteinsTissue DistributionAntineoplastic AgentsNitrilesPyrazolesRALA protein, humanRalb protein, humanral GTP-Binding ProteinsChemical synthesisRal inhibitorTissue distribution

Identifiers

PMID27825764
PMCPMC5301652

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.