Evidence map›Paper›PMID 27825537›Full record

ReviewTrends in cognitive sciences2016

Functional Connectivity of the Human Brain in Utero.

Marion I van den Heuvel, Moriah E Thomason

Abstract readReview
In one paragraph

Review in Trends in cognitive sciences, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
67citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

67 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
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  15. Neuronal Coupling Modes Show Differential Development in the Early Cortical Activity Networks of Human Newborns.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024
    Article
  16. Functional connectome through the human life span.bioRxiv : the preprint server for biology · 2024
    Article
  17. Review
  18. Article
  19. Article
  20. Article

7 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Marion I van den HeuvelMerrill Palmer Skillman Institute for Child and Family Development, Wayne State University, Detroit, MI, USA; Perinatology Research Branch, National Institute of Child Health and Human Development (NICHD)/National Institutes of Health (NIH)/Department of Health and Human Services (DHHS), Detroit, MI, USA.
Moriah E ThomasonMerrill Palmer Skillman Institute for Child and Family Development, Wayne State University, Detroit, MI, USA; Perinatology Research Branch, National Institute of Child Health and Human Development (NICHD)/National Institutes of Health (NIH)/Department of Health and Human Services (DHHS), Detroit, MI, USA; Department of Pediatrics, Wayne State University School of Medicine, Detroit, MI, USA. Electronic address: moriah@wayne.edu.

Funding

In Utero Assessment of the Human Neural Connectome and Later Child BehaviorR01MH110793 · NIMH · WAYNE STATE UNIVERSITY · PI THOMASON, MORIAH E · 2016 to 2021
$2.7M
Consequences of prenatal toxicant exposure on fetal brain functionR21ES026022 · NIEHS · MICHIGAN STATE UNIVERSITY · PI BURT, S. ALEXANDRA, THOMASON, MORIAH E · 2015 to 2016
$451k
Intramural NIH HHS Z99 HD999999NICHD NIH HHS HHSN275201300006CNIEHS NIH HHS R21 ES026022NIMH NIH HHS R01 MH110793
6 · The paper itself

Abstract

The brain is subject to dramatic developmental processes during the prenatal period. Nevertheless, information about the development of functional brain networks during gestation is scarce. Until recently it has not been possible to probe function in the living human fetal brain. Advances in functional MRI have changed the paradigm, making it possible to measure spontaneous activity in the fetal brain and to cross-correlate functional signals to attain information about neural connectional architecture across human gestation. We summarize the earliest MRI studies of fetal neural functional connectivity and highlight unique challenges and limitations inherent in the technique. In addition, we discuss future directions to unlock the potential of fetal brain functional MRI research.

Indexed as

Brain MappingNeural PathwaysBrainFetal DevelopmentGestational AgeHumansMagnetic Resonance Imagingbrain developmentfetusfunctional connectivitypregnancyresting-state

Identifiers

PMID27825537
PMCPMC5339022

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.