Signaling Boundary Conditions Drive Self-Organization of Human "Gastruloids".

Matthew Thomson

Open access · bronzeAbstract readComment

In one paragraph

Article in Developmental cell, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it

0cells of the map it votes in

2citing papers in PubMed

–field-weighted citation impact, top 88% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

Automated, High-Throughput Phenotypic Screening and Analysis Platform to Study Pre- and Post-Implantation Morphogenesis in Stem Cell-Derived Embryo-Like Structures.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
Article
From Snapshots to Development: Identifying the Gaps in the Development of Stem Cell-based Embryo Models along the Embryonic Timeline.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021
Review

4 · The record

Corrections and comments

Comment on
A Balance between Secreted Inhibitors and Edge Sensing Controls Gastruloid Self-Organization.2016

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Matthew ThomsonCenter for Systems and Synthetic Biology, University of California San Francisco, Genentech Hall Rm. S472, 600 16th St., San Francisco, CA 94158, USA; Department of Biology and Bioengineering, California Institute of Technology, 1200 E California Blvd, Pasadena, CA 91125, USA. Electronic address: matthew.thomson@ucsf.edu.

California Institute of Technology · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Morphogenesis requires tissues to sense and respond to their geometry. In this issue of Developmental Cell, Etoc et al. (2016) show that a confined colony of human embryonic stem cells can spontaneously sense its boundary, generating a self-organized TGF-β signaling gradient that patterns it into a tissue resembling a gastrulating embryo.

Indexed as

MorphogenesisSignal TransductionHumansTransforming Growth Factor betaTransforming Growth Factor beta

Identifiers

PMID27825435

DOI10.1016/j.devcel.2016.10.016

OpenAlexW2551224148

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.