ArticlePsychological medicine2017
Neighborhood deprivation and depression in adult twins: genetics and gene×environment interaction.
Article in Psychological medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 40 citations in OpenAlex.
- Neighborhood Deprivation, Trauma Profiles, Coping, and Stress Prospectively Predict Depressive Symptoms Among Young African American Mothers in the InterGEN Study: A Latent Class Analysis.Journal of racial and ethnic health disparities · 2026Article
- Depression and Crime Across Different Neighborhoods in the Swedish General Population.JAMA network open · 2026Article
- Cognitive functioning in context: Leisure activity engagement, social capital, and urbanicity-rurality interplay.PloS one · 2026Article
- Polygenic scores for depression are associated with indices of neighborhood adversity.Journal of psychopathology and clinical science · 2025Article
- The development of an environmental risk score using Swedish National Registers and its impact on subsequent episodes of major depression.Psychological medicine · 2025Article
- Neighborhood context, genetic influences, and life satisfaction: Evidence from the German twin family panel.PloS one · 2025Article
- Socioeconomic status, personality, and major mental disorders: a bidirectional Mendelian randomization study.Schizophrenia (Heidelberg, Germany) · 2024Article
- Does neighbourhood deprivation influence low back pain and arthritis: An empirical study using multilevel twin design.PloS one · 2024Article
- Patterns of depression symptoms in relation to stressors and social behaviors during the COVID-19 pandemic among older youth and emerging adults in the United States.PLOS global public health · 2024Article
- Clinical practice guidelines on the environment and mental well-being.Indian journal of psychiatry · 2024Article
- [Effects of Television Screen Exposure on the Mental Health of Middle-aged and Older Adults].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2023Article
- A gene-environment cascade theoretical framework of developmental psychopathology.Journal of psychopathology and clinical science · 2023Article
- Disadvantage and disordered eating in boys: Examining phenotypic and genotype × environment associations across development.Journal of psychopathology and clinical science · 2023Article
- Article
- Neighborhood deprivation and coronary heart disease in patients with bipolar disorder.Scientific reports · 2022Article
- Biological, Psychological, and Social Determinants of Depression: A Review of Recent Literature.Brain sciences · 2021Review
- Context matters: Neighborhood disadvantage is associated with increased disordered eating and earlier activation of genetic influences in girls.Journal of abnormal psychology · 2021Article
- The Contribution of Neighborhood Socioeconomic Disadvantage to Depressive Symptoms Over the Course of Adult Life: A 32-Year Prospective Cohort Study.American journal of epidemiology · 2020Article
- Neighborhood Deprivation Moderates Shared and Unique Environmental Influences on Hazardous Drinking: Findings from a Cross-Sectional Co-Twin Study.Substance use & misuse · 2020Article
- Genetic influences on treatment-seeking for common mental health problems in the UK biobank.Behaviour research and therapy · 2019Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundDepression is a significant problem and it is vital to understand its underlying causes and related policy implications. Neighborhood characteristics are implicated in depression but the nature of this association is unclear. Unobserved or unmeasured factors may confound the relationship. This study addresses confounding in a twin study investigating neighborhood-level effects on depression controlling for genetics, common environment, and gene×environment (G × E) interactions.
methodData on neighborhood deprivation and depression were gathered from 3155 monozygotic twin pairs and 1275 dizygotic pairs (65.7% female) between 2006 and 2013. The variance for both depression and neighborhood deprivation was decomposed into three components: additive genetic variance (A); shared environmental variance (C); and non-shared environmental variance (E). Depression was then regressed on neighborhood deprivation to test the direct association and whether that association was confounded. We also tested for a G × E interaction in which the heritability of depression was modified by the level of neighborhood deprivation.
resultsDepression and neighborhood deprivation showed evidence of significant A (21.8% and 15.9%, respectively) and C (13.9% and 32.7%, respectively) variance. Depression increased with increasing neighborhood deprivation across all twins (p = 0.009), but this regression was not significant after controlling for A and C variance common to both phenotypes (p = 0.615). The G × E model showed genetic influences on depression increasing with increasing neighborhood deprivation (p < 0.001).
conclusionsNeighborhood deprivation is an important contributor to depression via increasing the genetic risk. Modifiable pathways that link neighborhoods to depression have been proposed and should serve as targets for intervention and research.
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