Inhibiting the proton pump: mechanisms, benefits, harms, and questions.

Jeffrey K Aronson

Open access · goldAbstract readComment

In one paragraph

Article in BMC medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it

0cells of the map it votes in

6citing papers in PubMed

2.0field-weighted citation impact, top 13% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 19 citations in OpenAlex.

Comparative renal safety: potassium-competitive acid blockers vs proton pump inhibitors.Clinical kidney journal · 2026
Article
Wood calamint ameliorates ethanol-induced stomach injury in rats by augmentation of hsp/bax and inflammatory mechanisms.Journal of molecular histology · 2024
Article
Insights into Effects/Risks of Chronic Hypergastrinemia and Lifelong PPI Treatment in Man Based on Studies of Patients with Zollinger-Ellison Syndrome.International journal of molecular sciences · 2019
Review
Tumour acidosis: from the passenger to the driver's seat.Nature reviews. Cancer · 2017
Review
Gastrin and Gastric Cancer.Frontiers in endocrinology · 2017
Review
The relationship between proton pump inhibitors and renal disease.Jornal brasileiro de nefrologia
Review

4 · The record

Corrections and comments

Comment on
Effective and safe proton pump inhibitor therapy in acid-related diseases - A position paper addressing benefits and potential harms of acid suppression.2016

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Jeffrey K AronsonCentre for Evidence-Based Medicine, Nuffield Department of Primary Care Health Sciences, University of Oxford, Radcliffe Observatory Quarter, Oxford, OX2 6GG, UK. jeffrey.aronson@phc.ox.ac.uk.

University of Oxford · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Inhibition of the H

Indexed as

Proton Pump InhibitorsProton PumpsAnti-Inflammatory Agents, Non-SteroidalGastroesophageal RefluxHelicobacter pyloriHumansAnti-Inflammatory Agents, Non-SteroidalProton Pump InhibitorsProton PumpsAdverse drug reactionsBenefitsDrug–drug interactionsHarmsProton pump inhibitors

Identifiers

PMID27825384

DOI10.1186/s12916-016-0724-1

PMCPMC5101661

OpenAlexW2543230789

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.