ArticleBMC biology2016
Predicting Wolbachia invasion dynamics in Aedes aegypti populations using models of density-dependent demographic traits.
Article in BMC biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A Systematic Review of Mathematical Models of Dengue Transmission and Vector Control: 2010-2020.Viruses · 2023Pooled it
- Review
- Introduction ofiScience · 2024Article
- Insect population dynamics under Wolbachia-induced cytoplasmic incompatibility: Puzzle more than buzz in Drosophila suzukii.PloS one · 2024Article
- Article
- High Temperature Cycles Result in Maternal Transmission and Dengue Infection Differences BetweenmBio · 2021Article
- Modeling the effects of Aedes aegypti's larval environment on adult body mass at emergence.PLoS computational biology · 2021Article
- Gene Drive Dynamics in Natural Populations: The Importance of Density Dependence, Space, and Sex.Annual review of ecology, evolution, and systematics · 2020Article
- Modeling and dynamics of Wolbachia-infected male releases and mating competition on mosquito control.Journal of mathematical biology · 2020Article
- The Role of Vector Trait Variation in Vector-Borne Disease Dynamics.Frontiers in ecology and evolution · 2020Article
- Population Dynamics of Underdominance Gene Drive Systems in Continuous Space.ACS synthetic biology · 2020Article
- Efficient production of male Wolbachia-infected Aedes aegypti mosquitoes enables large-scale suppression of wild populations.Nature biotechnology · 2020Article
- Wolbachia strain wAlbA blocks Zika virus transmission in Aedes aegypti.Medical and veterinary entomology · 2020Article
- Wolbachia transinfections in Culex quinquefasciatus generate cytoplasmic incompatibility.Insect molecular biology · 2020Article
- Aedes aegypti insecticide resistance underlies the success (and failure) of Wolbachia population replacement.Scientific reports · 2020Article
- Artificial Selection Finds New Hypotheses for the Mechanism ofFrontiers in microbiology · 2020Article
- Cytoplasmic incompatibility management to support Incompatible Insect Technique against Aedes albopictus.Parasites & vectors · 2018Article
- Recent advances in threshold-dependent gene drives for mosquitoes.Biochemical Society transactions · 2018Review
- Small females prefer small males: size assortative mating in Aedes aegypti mosquitoes.Parasites & vectors · 2018Article
- Population dynamics of engineered underdominance and killer-rescue gene drives in the control of disease vectors.PLoS computational biology · 2018Article
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5 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundArbovirus transmission by the mosquito Aedes aegypti can be reduced by the introduction and establishment of the endosymbiotic bacteria Wolbachia in wild populations of the vector. Wolbachia spreads by increasing the fitness of its hosts relative to uninfected mosquitoes. However, mosquito fitness is also strongly affected by population size through density-dependent competition for limited food resources. We do not understand how this natural variation in fitness affects symbiont spread, which limits our ability to design successful control strategies.
resultsWe develop a mathematical model to predict A. aegypti-Wolbachia dynamics that incorporates larval density-dependent variation in important fitness components of infected and uninfected mosquitoes. Our model explains detailed features of the mosquito-Wolbachia dynamics observed in two independent experimental A. aegypti populations, allowing the combined effects on dynamics of multiple density-dependent fitness components to be characterized. We apply our model to investigate Wolbachia field release dynamics, and show how invasion outcomes can depend strongly on the severity of density-dependent competition at the release site. Specifically, the ratio of released relative to wild mosquitoes required to attain a target infection frequency (at the end of a release program) can vary by nearly an order of magnitude. The time taken for Wolbachia to become established following releases can differ by over 2 years. These effects depend on the relative fitness of field and insectary-reared mosquitoes.
conclusionsModels of Wolbachia invasion incorporating density-dependent demographic variation in the host population explain observed dynamics in experimental A. aegypti populations. These models predict strong effects of density-dependence on Wolbachia dynamics in field populations, and can assist in the effective use of Wolbachia to control the transmission of arboviruses such as dengue, chikungunya and zika.
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