ArticleBMC complementary and alternative medicine2016
Essential oils: in vitro activity against Leishmania amazonensis, cytotoxicity and chemical composition.
Article in BMC complementary and alternative medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 82 citations in OpenAlex.
- Effect of essential oils onParasitology · 2020Pooled it
- Therapeutic Effects of Matricaria chamomilla Extract in an Immunosuppressed Mouse Model of Cryptosporidiosis.Veterinary medicine and science · 2026Article
- Bioactivity ofMolecules (Basel, Switzerland) · 2026Article
- Multivariate Characterization of Essential Oils for Their Antibacterial Activity AgainstMolecules (Basel, Switzerland) · 2026Article
- Recurrent Sesquiterpenes in Siparuna guianensis Essential Oil: Therapeutic Potential and Pharmacokinetic Insights.BioMed research international · 2026Review
- Molecular docking and simulation analysis of selected herbal compounds against GP63, FPPS, and NMT, three importantResearch in pharmaceutical sciences · 2025Article
- Anti-Trypanosomatidae Activity of Essential Oils and Their Main Components from Selected Medicinal Plants.Molecules (Basel, Switzerland) · 2023Article
- Antibacterial, Antiparasitic, and Cytotoxic Activities of Chemical Characterized Essential Oil ofPharmaceuticals (Basel, Switzerland) · 2022Article
- Quantum Biochemistry Screening and In Vitro Evaluation ofInternational journal of molecular sciences · 2022Article
- Machine Learning Analysis of Essential Oils from Cuban Plants: Potential Activity against Protozoa Parasites.Molecules (Basel, Switzerland) · 2022Article
- Essential oils from Syzygium aromaticum and Zingiber officinale, administered alone or in combination with benznidazole, reduce the parasite load in mice orally inoculated with Trypanosoma cruzi II.BMC complementary medicine and therapies · 2021Article
- In vitro Antileishmanial Activity of Some Ethiopian Medicinal Plants.Journal of experimental pharmacology · 2021Article
- Phytochemical Screening and Antiprotozoal Effects of the MethanolicMolecules (Basel, Switzerland) · 2020Article
- Metabolic Profile, Bioactivities, and Variations in the Chemical Constituents of Essential Oils of theFrontiers in pharmacology · 2020Review
- Prolyl Oligopeptidase FromFrontiers in microbiology · 2020Article
- Untargeted LC-MS metabolomic studies of Asteraceae species to discover inhibitors of Leishmania major dihydroorotate dehydrogenase.Metabolomics : Official journal of the Metabolomic Society · 2019Article
- Chemo-Diversity and Antiradical Potential of TwelveMolecules (Basel, Switzerland) · 2019Article
- In-Vitro Evaluation of 52 Commercially-Available Essential Oils AgainstMolecules (Basel, Switzerland) · 2019Article
- Active Essential Oils and Their Components in Use against Neglected Diseases and Arboviruses.Oxidative medicine and cellular longevity · 2019Review
- Asteraceae Plants as Sources of Compounds Against Leishmaniasis and Chagas Disease.Frontiers in pharmacology · 2019Review
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe current chemotherapy for cutaneous leishmaniosis (CL) has a series of drug limitations such as toxic side effects, long duration, high costs and drug resistance, which requires the development of new drugs or effective alternatives to the CL treatment. Essential oils (EOs) are complex mixtures of secondary metabolites from various plants. It has been shown that several EOs, or their constituents, have inhibitory activity against protozoa. Thus, this study aims to evaluate the biological activity of different essential oils (EOs) on Leishmania (L.) amazonensis promastigotes forms, as well as their cytotoxicity on mammalian cells and chemical composition.
methodsSixteen EOs were evaluated by mean of IC
resultsThe EO from Cinnamodendron dinisii, Matricaria chamomilla, Myroxylon peruiferum, Salvia sclarea, Bulnesia sarmientoi, Ferula galbaniflua, Siparuna guianensis and Melissa officinalis were the most active against L. amazonensis with IC50/24 h ranging from 54.05 to 162.25 μg/mL. Analysis of EOs by GC-MS showed mainly the presence of β-farnesene (52.73 %) and bisabolol oxide (12.09 %) for M. chamomilla; α-copaene (13.41 %), safrole (8.35 %) and δ-cadinene (7.08 %) for M. peruiferum; linalool (28.80 %) and linalyl acetate (60.08 %) for S. sclarea; guaiol (48.29 %) and 2-undecanone (19.49 %) for B. sarmientoi; ethyl phthalate (13.09 %) and methyl-8-pimaren-18-oate (41.82 %) for F. galbaniflua; and neral (37.18 %) and citral (5.02 %) for M. officinalis.
conclusionThe EO from F. galbaniflua showed to be effective against L. amazonensis promastigotes forms and presented low cytotoxic activity against L6 cells. Thus, it represents a strong candidate for future studies aiming its molecular activity on these pathogenic parasites.
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