ArticleBMC infectious diseases2016
Prevalence of latent tuberculosis infection and predictive factors in an urban informal settlement in Johannesburg, South Africa: a cross-sectional study.
Article in BMC infectious diseases, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 54 citations in OpenAlex.
- Comparison of QuantiFERON Gold In-Tube Versus Tuberculin Skin Tests on the Initiation of Tuberculosis Preventive Therapy Among Patients Newly Diagnosed With HIV in the North West Province of South Africa (the Teko Study): A Cluster Randomized Trial.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2024Trial
- Risk Factors for Immunological Sensitization to Mycobacterium tuberculosis and Progression to Incident TB Disease Among HIV-uninfected Adults in a High Burden Setting.The Journal of infectious diseases · 2026Article
- Performance of whole blood interferon-γ release assays in SARS-CoV-2 and tuberculosis is age dependent.Infection · 2025Article
- Evaluating the New TB Antigen-Based Skin Test to Diagnose TB Infection in South Africa.Tropical medicine and infectious disease · 2025Article
- Tuberculosis Preventive Treatment for Pregnant People With HIV in South Africa: A Modeling Analysis of Clinical Benefits and Risks.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2025Article
- Incident Tuberculosis Infection Is Associated With Alcohol Use in Adults in Rural Uganda.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2025Article
- Sex differences in tuberculosis infection and disease among people with HIV.AIDS (London, England) · 2025Article
- Prediction models for Mtb infection among adolescent and adult household contacts in high tuberculosis incidence settings.PLOS global public health · 2025Article
- Prevalence, incidence and determinants of QuantiFERONIJTLD open · 2024Article
- Strong effect of demographic changes on Tuberculosis susceptibility in South Africa.PLOS global public health · 2024Article
- Burden of tuberculosis in underserved populations in South Africa: A systematic review and meta-analysis.PLOS global public health · 2024Article
- Exposure to bovine livestock and latent tuberculosis infection in children: Investigating the zoonotic tuberculosis potential in a large urban and peri-urban area of Cameroon.PLOS global public health · 2024Article
- Public Health Impact and Cost-Effectiveness of Screening for Active Tuberculosis Disease or Infection Among Children in South Africa.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2023Article
- Strong Effect of Demographic Changes on Tuberculosis Susceptibility in South Africa.medRxiv : the preprint server for health sciences · 2023Article
- Prevalence and predictors of tuberculosis infection among people living with HIV in a high tuberculosis burden context.BMJ open respiratory research · 2023Article
- Sex and Gender Differences in Tuberculosis Pathogenesis and Treatment Outcomes.Current topics in microbiology and immunology · 2023Review
- Association between prior tuberculosis disease and dysglycemia within an HIV-endemic, rural South African population.PloS one · 2023Article
- Magnitude and associated factors of latent tuberculosis infection due toIJID regions · 2022Article
- Possible sex difference in latent tuberculosis infection risk among close tuberculosis contacts.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2022Observational
- Prevalence of Latent Tuberculosis Infection Among Healthy Young Children and Adolescents and a Two-step Approach for the Diagnosis of Tuberculosis Infection in Chengdu, China.The Pediatric infectious disease journal · 2022Article
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Authors and funding
11 authors at 3 institutions in 3 countries.
Funding
Abstract
backgroundSouth Africa has one of the highest burdens of latent tuberculosis infection (LTBI) in high-risk populations such as young children, adolescents, household contacts of TB cases, people living with HIV, gold miners and health care workers, but little is known about the burden of LTBI in its general population.
methodsUsing a community-based survey with random sampling, we examined the burden of LTBI in an urban township of Johannesburg and investigated factors associated with LTBI. The outcome of LTBI was based on TST positivity, with a TST considered positive if the induration was ≥5 mm in people living with HIV or ≥10 mm in those with unknown or HIV negative status. We used bivariate and multivariable logistic regression to identify factors associated with LTBI
resultsThe overall prevalence of LTBI was 34.3 (95 % CI 30.0, 38.8 %), the annual risk of infection among children age 0-14 years was 3.1 % (95 % CI 2.1, 5.2). LTBI was not associated with HIV status. In multivariable logistic regression analysis, LTBI was associated with age (OR = 1.03 for every year increase in age, 95 % CI = 1.01-1.05), male gender (OR = 2.70, 95 % CI = 1.55-4.70), marital status (OR = 2.00, 95 % CI = 1.31-3.54), and higher socio-economic status (OR = 2.11, 95 % CI = 1.04-4.31).
conclusionsThe prevalence of LTBI and the annual risk of infection with M. tuberculosis is high in urban populations, especially in men, but independent of HIV infection status. This study suggests that LTBI may be associated with higher SES, in contrast to the well-established association between TB disease and poverty.
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