Evidence map›Paper›PMID 27825106›Full record

ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2017

Macrophage migration inhibitory factor protects from nonmelanoma epidermal tumors by regulating the number of antigen-presenting cells in skin.

Tania Brocks, Oleg Fedorchenko, Nicola Schliermann, Astrid Stein, Ute M Moll, Seth Seegobin, Manfred Dewor, Michael Hallek, Yvonne Marquardt, Katharina Fietkau and 7 more

Open access · bronzeAbstract read
In one paragraph

Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 25 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Haplotypes of [-794(CATT)Molecular genetics & genomic medicine · 2023
    Article
  5. Article
  6. Melanoma stimulates the proteolytic activity of HaCaT keratinocytes.Cell communication and signaling : CCS · 2022
    Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Assessment of macrophage migration inhibitory factor in patients with verruca vulgaris.Clinical, cosmetic and investigational dermatology · 2019
    Article
  14. Article
  15. Article
  16. Article
  17. Frontiers in immunology · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 6 institutions in 3 countries.

Tania BrocksDepartment I of Internal Medicine, University Hospital Cologne, Cologne, Germany.
Oleg FedorchenkoDepartment I of Internal Medicine, University Hospital Cologne, Cologne, Germany.
Nicola SchliermannDepartment I of Internal Medicine, University Hospital Cologne, Cologne, Germany.
Astrid SteinInstitute of Pathology and Cytology, University Hospital Cologne, Cologne, Germany.
Ute M MollDepartment of Pathology, Stony Brook University, Stony Brook, New York, USA.
Seth SeegobinDepartment of Medical and Molecular Genetics, School of Medicine, Guy's Hospital, King's College London, London, United Kingdom.
Manfred DeworInstitute of Biochemistry and Molecular Cell Biology Rheinisch-Westfälische Technische Hochschule, Aachen, Germany.
Michael HallekDepartment I of Internal Medicine, University Hospital Cologne, Cologne, Germany.
Yvonne MarquardtDepartment of Dermatology, Rheinisch-Westfälische Technische Hochschule, Aachen, Germany.
Katharina FietkauDepartment of Dermatology, Rheinisch-Westfälische Technische Hochschule, Aachen, Germany.
Ruth HeiseDepartment of Dermatology, Rheinisch-Westfälische Technische Hochschule, Aachen, Germany.
Sebastian HuthDepartment of Dermatology, Rheinisch-Westfälische Technische Hochschule, Aachen, Germany.
Herbert PfisterInstitute of Virology, University Hospital Cologne, Cologne, Germany.
Juergen BernhagenInstitute of Biochemistry and Molecular Cell Biology Rheinisch-Westfälische Technische Hochschule, Aachen, Germany.
Richard BucalaDepartment of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, USA.
Jens M BaronDepartment of Dermatology, Rheinisch-Westfälische Technische Hochschule, Aachen, Germany.
Guenter Fingerle-RowsonDepartment I of Internal Medicine, University Hospital Cologne, Cologne, Germany; g.fingerle-rowson@gmx.de.
Westfälische Hochschule · DEUniversity Hospital Cologne · DEIntegrated Oncology (United States) · USGuy's Hospital · GBMolecular Oncology (United States) · USYale University · US

Funding

Yale Pathology Tissue Services Shared ResourceP30CA016359 · NCI · YALE UNIVERSITY · PI DAVID L RIMM · 1985 to 2026
$85.0M
MIF AND THE HOST RESPONSE TO INFECTIONR01AI042310 · NIAID · YALE UNIVERSITY · PI BUCALA, RICHARD J · 1998 to 2013
$4.3M
MIF and Host Response to InfectionR56AI042310 · NIAID · YALE UNIVERSITY · PI BUCALA, RICHARD J · 2014 to 2014
$426k
NIAID NIH HHS R01 AI042310NIAID NIH HHS R56 AI042310
6 · The paper itself

Abstract

The response of the skin to harmful environmental agents is shaped decisively by the status of the immune system. Keratinocytes constitutively express and secrete the chemokine-like mediator, macrophage migration inhibitory factor (MIF), more strongly than dermal fibroblasts, thereby creating a MIF gradient in skin. By using global and epidermis-restricted Mif-knockout (Mif

Indexed as

AnimalsAnthracenesAntigens, CDCarcinogenesisGene Expression RegulationInflammationKeratinocytesMacrophage Migration-Inhibitory FactorsMiceMice, Inbred BALB CMice, KnockoutMice, TransgenicPiperidinesPyridinesReceptors, CXCRSkin3-(2,6-bis(4-fluorophenyl)-3-methylpiperidin-4-ylideneamino)-2-thioxoimidazolidin-4-one on 7,12-dimethylbenz(a)anthraceneAnthracenesAntigens, CDMacrophage Migration-Inhibitory FactorsPiperidinesPyridinesReceptors, CXCRtris(2-pyridylmethyl)amineCD44CD74chemokineDMBA/TPAskin carcinogenesis

Identifiers

PMID27825106
PMCPMC6137604
OpenAlexW2535749184

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.