ArticlePloS one2016
Identification of Anion Channels Responsible for Fluoride Resistance in Oral Streptococci.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 39 citations in OpenAlex.
- Effect of a sodium fluoride rinse on the composition of early oral biofilms formed in situ on enamel and dentine.Clinical oral investigations · 2026Trial
- Recent Advances in Caries Prevention and Non-Invasive Management: From Ecological Modulation to Precision Interventions.Dentistry journal · 2026Review
- Microbial populations under fluoride stress: a metagenomic exploration from Indian soil.World journal of microbiology & biotechnology · 2025Article
- The physical biogeography ofmBio · 2025Article
- Non-Thermal Atmospheric Plasma Enhances Biological Effects of Fluoride on Oral Biofilms.Journal of functional biomaterials · 2025Article
- The link between ancient microbial fluoride resistance mechanisms and bioengineering organofluorine degradation or synthesis.Nature communications · 2024Review
- Article
- Metabolomics reveals high fructose-1,6-bisphosphate from fluoride-resistant Streptococcus mutans.BMC microbiology · 2024Article
- Fluoride export is required for competitive fitness of pathogenic microorganisms in dental biofilm models.bioRxiv : the preprint server for biology · 2024Article
- Fluoride-resistantFrontiers in microbiology · 2024Article
- Measurement and analysis of microbial fluoride resistance in dental biofilm models.Methods in enzymology · 2024Article
- Transposon mutagenesis in oralJournal of oral microbiology · 2022Review
- Influence of Fluoride-ResistantFrontiers in cellular and infection microbiology · 2022Article
- Ecological influence by colonization of fluoride-resistantFrontiers in cellular and infection microbiology · 2022Article
- Membrane Exporters of Fluoride Ion.Annual review of biochemistry · 2021Review
- Genetic Mutations That Confer Fluoride Resistance Modify Gene Expression and Virulence Traits ofMicroorganisms · 2021Article
- FFrontiers in microbiology · 2021Article
- Biological approaches of fluoride remediation: potential for environmental clean-up.Environmental science and pollution research international · 2020Review
- Fluoride contributes to the shaping of microbial community in high fluoride groundwater in Qiji County, Yuncheng City, China.Scientific reports · 2019Article
- Genetics ofMicrobiology spectrum · 2019Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recently, it has been reported that eriC and crcB are involved in bacterial fluoride resistance. However, the fluoride-resistance mechanism in oral streptococci remains unclear. BLAST studies showed that two types of eriCs (eriC1 and eriC2) and two types of crcBs (crcB1 and crcB2) are present across 18 oral streptococci, which were identified in ≥ 10% of 166 orally healthy subjects with ≥ 0.01% of the mean relative abundance. They were divided into three groups based on the distribution of these four genes: group I, only eriC1; group II, eriC1 and eriC2; and group III, eriC2, crcB1, and crcB2. Group I consisted of Streptococcus mutans, in which one of the two eriC1s predominantly affected fluoride resistance. Group II consisted of eight species, and eriC1 was responsible for fluoride resistance, but eriC2 was not, in Streptococcus anginosus as a representative species. Group III consisted of nine species, and both crcB1 and crcB2 were crucial for fluoride resistance, but eriC2 was not, in Streptococcus sanguinis as a representative species. Based on these results, either EriC1 or CrcBs play a role in fluoride resistance in oral streptococci. Complementation between S. mutans EriC1 and S. sanguinis CrcB1/CrcB2 was confirmed in both S. mutans and S. sanguinis. However, neither transfer of S. sanguinis CrcB1/CrcB2 into wild-type S. mutans nor S. mutans EriC1 into wild-type S. sanguinis increased the fluoride resistance of the wild-type strain. Co-existence of different F- channels (EriC and CrcB) did not cause the additive effect on fluoride resistance in oral Streptococcus species.
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