Evidence map›Paper›PMID 27824812›Full record

ArticleBritish journal of cancer2017

Projected cancer risks potentially related to past, current, and future practices in paediatric CT in the United Kingdom, 1990-2020.

Neige M Y Journy, Choonsik Lee, Richard W Harbron, Kieran McHugh, Mark S Pearce, Amy Berrington de González

Open access · hybridAbstract read
In one paragraph

Article in British journal of cancer, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
4.8field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 56 citations in OpenAlex.

  1. Article
  2. Review
  3. Patient-specific organ dose calculation using automatic segmentation and extension of CT scans.Radiation physics and chemistry (Oxford, England : 1993) · 2025
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Neuroimaging in the term newborn with neonatal encephalopathy.Seminars in fetal & neonatal medicine · 2021
    Review
  10. Article
  11. Article
  12. Article
  13. Frontiers in neurology · 2019
    Article
  14. Article
  15. Review
  16. Review
  17. Article
  18. Operational and Dosimetric Aspects of Pediatric PET/CT.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2017
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 2 countries.

Neige M Y JournyRadiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 9609 Medical Center Drive, MSC 9776, Bethesda, Maryland 20892, USA.
Choonsik LeeRadiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 9609 Medical Center Drive, MSC 9776, Bethesda, Maryland 20892, USA.
Richard W HarbronInstitute of Health & Society, Newcastle University, Royal Victoria Infirmary, Queen Victoria Road, Newcastle-upon-Tyne NE1 4LP, UK.
Kieran McHughGreat Ormond Street Hospital for Children, Great Ormond Street, London WC1N 3JH, UK.
Mark S PearceInstitute of Health & Society, Newcastle University, Royal Victoria Infirmary, Queen Victoria Road, Newcastle-upon-Tyne NE1 4LP, UK.
Amy Berrington de GonzálezRadiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 9609 Medical Center Drive, MSC 9776, Bethesda, Maryland 20892, USA.
National Institutes of Health · USNewcastle University · GBRoyal Victoria Infirmary · GBUniversity College London · GB

Funding

Studies of Populations Exposed to Diagnostic Medical RadiationZIACP010222 · NCI · DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS · PI KITAHARA, CARI · 2011 to 2025
$13.1M
Cancer Research UK 16015
6 · The paper itself

Abstract

backgroundTo project risks of developing cancer and the number of cases potentially induced by past, current, and future computed tomography (CT) scans performed in the United Kingdom in individuals aged <20 years.

methodsOrgan doses were estimated from surveys of individual scan parameters and CT protocols used in the United Kingdom. Frequencies of scans were estimated from the NHS Diagnostic Imaging Dataset. Excess lifetime risks (ELRs) of radiation-related cancer were calculated as cumulative lifetime risks, accounting for survival probabilities, using the RadRAT risk assessment tool.

resultsIn 2000-2008, ELRs ranged from 0.3 to 1 per 1000 head scans and 1 to 5 per 1000 non-head scans. ELRs per scan were reduced by 50-70% in 2000-2008 compared with 1990-1995, subsequent to dose reduction over time. The 130 750 scans performed in 2015 in the United Kingdom were projected to induce 64 (90% uncertainty interval (UI): 38-113) future cancers. Current practices would lead to about 300 (90% UI: 230-680) future cancers induced by scans performed in 2016-2020.

conclusionsAbsolute excess risks from single exposures would be low compared with background risks, but even small increases in annual CT rates over the next years would substantially increase the number of potential subsequent cancers.

Indexed as

ForecastingAdolescentChildChild, PreschoolFemaleHumansInfantInfant, NewbornMaleNeoplasms, Radiation-InducedPediatriciansPractice Patterns, Physicians'Radiation DosageRisk AssessmentTomography, X-Ray ComputedUnited Kingdom

Identifiers

PMID27824812
PMCPMC5220140
OpenAlexW2552171512

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.