Evidence map›Paper›PMID 27824591›Full record

ReviewJournal of immunology (Baltimore, Md. : 1950)2016

NK Cell Responses Redefine Immunological Memory.

Nicholas M Adams, Timothy E O'Sullivan, Clair D Geary, Jenny M Karo, Robert A Amezquita, Nikhil S Joshi, Susan M Kaech, Joseph C Sun

Abstract readReview
In one paragraph

Review in Journal of immunology (Baltimore, Md. : 1950), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Increased Complement Receptor-3 levels in monocytes and granulocytes distinguish COVID-19 patients with pneumonia from those with mild symptoms.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2020
    Article
  7. Article
  8. Review
  9. Review
  10. Review
  11. Review
  12. Review
  13. Article
  14. Review
  15. Epigenomic Views of Innate Lymphoid Cells.Frontiers in immunology · 2017
    Review
  16. Article
  17. Human CD56Frontiers in immunology · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Nicholas M AdamsImmunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065.ORCID 0000-0001-5751-0480
Timothy E O'SullivanImmunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065.ORCID 0000-0002-0104-4932
Clair D GearyImmunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065.
Jenny M KaroImmunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065.
Robert A AmezquitaDepartment of Immunobiology, Yale University School of Medicine, New Haven, CT 06520; and.ORCID 0000-0001-6868-7193
Nikhil S JoshiDepartment of Immunobiology, Yale University School of Medicine, New Haven, CT 06520; and.ORCID 0000-0002-7045-7837
Susan M KaechDepartment of Immunobiology, Yale University School of Medicine, New Haven, CT 06520; and.
Joseph C SunImmunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065; sunj@mskcc.org.

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Weill Cornell/Rockefeller/Sloan-Kettering MST ProgramT32GM007739 · NIGMS · WEILL MEDICAL COLL OF CORNELL UNIV · PI HSU, KATHARINE C · 1985 to 2023
$51.1M
The natural killer cell response against mouse cytomegalovirus infectionR01AI100874 · NIAID · SLOAN-KETTERING INST CAN RESEARCH · PI Joseph Chai-Yuen Sun · 2012 to 2026
$7.4M
Natural killer cell responses against viral infectionR00AI085034 · NIAID · SLOAN-KETTERING INST CAN RESEARCH · PI SUN, JOSEPH CHAI-YUEN · 2010 to 2011
$498k
NCATS NIH HHS UL1 TR001863NCI NIH HHS P30 CA008748NIAID NIH HHS R00 AI085034NIAID NIH HHS R01 AI100874NIGMS NIH HHS T32 GM007739
6 · The paper itself

Abstract

Immunological memory has traditionally been regarded as a unique trait of the adaptive immune system. Nevertheless, there is evidence of immunological memory in lower organisms and invertebrates, which lack an adaptive immune system. Despite their innate ability to rapidly produce effector cytokines and kill virally infected or transformed cells, NK cells also exhibit adaptive characteristics such as clonal expansion, longevity, self-renewal, and robust recall responses to antigenic or nonantigenic stimuli. In this review, we highlight the intracellular and extracellular requirements for memory NK cell generation and describe the emerging evidence for memory precursor NK cells and their derivation.

Indexed as

Adaptive ImmunityImmunologic MemoryAnimalsCell DifferentiationHumansImmunity, InnateInvertebratesKiller Cells, Natural

Identifiers

PMID27824591
PMCPMC5108457

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.