ArticleTranslational psychiatry2016
High-field magnetic resonance imaging of structural alterations in first-episode, drug-naive patients with major depressive disorder.
Article in Translational psychiatry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 3 of them syntheses that pooled it.
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Who cites it
35 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- The Dark and Gloomy Brain: Grey Matter Volume Alterations in Major Depressive Disorder-Fine-Grained Meta-Analyses.Depression and anxiety · 2024Pooled it
- Reduced Brain Gray Matter Volume in Patients With First-Episode Major Depressive Disorder: A Quantitative Meta-Analysis.Frontiers in psychiatry · 2021Pooled it
- Cognitive impairment and depression: Meta-analysis of structural magnetic resonance imaging studies.NeuroImage. Clinical · 2021Pooled it
- Esketamine relieves postoperative depression and pain indicators in patients undergoing laparoscopic total hysterectomy.BMC anesthesiology · 2025Trial
- Functional Connectivity Changes Associated With Depression in Dementia With Lewy Bodies.International journal of geriatric psychiatry · 2025Trial
- 3DViT-GAT: a unified atlas-based 3D vision transformer and graph learning framework for major depressive disorder detection using structural MRI data.Scientific reports · 2026Article
- Gray Matter Volume Correlates of Co-Occurring Depression in Autism Spectrum Disorder.Journal of autism and developmental disorders · 2026Article
- Observational
- Two subtypes of major depressive disorder are identified from individualized gray matter morphological abnormalities in a large multi-site dataset.Psychological medicine · 2025Article
- Detection of Major Depressive Disorder from Functional Magnetic Resonance Imaging Using Regional Homogeneity and Feature/Sample Selective Evolving Voting Ensemble Approaches.Journal of imaging · 2025Article
- Multi-omics analyses of the gut microbiome, fecal metabolome, and multimodal brain MRI reveal the role ofPsychological medicine · 2025Article
- Novel Gene-Informed Regional Brain Targets for Clinical Screening for Major Depression.Neurology international · 2025Article
- Disrupted intersubject variability architecture in structural and functional brain connectomes in major depressive disorder.Psychological medicine · 2025Article
- Common neuroanatomical differential factors underlying heterogeneous gray matter volume variations in five common psychiatric disorders.Communications biology · 2025Article
- The Role of Inflammation in Depression and Beyond: A Primer for Clinicians.Current psychiatry reports · 2024Review
- Major depressive disorder: hypothesis, mechanism, prevention and treatment.Signal transduction and targeted therapy · 2024Review
- White and Gray Matter Abnormalities in Young Adult Females with Dependent Personality Disorder: A Diffusion-Tensor Imaging and Voxel-Based Morphometry Study.Brain topography · 2024Article
- Reduced cerebral cortex thickness is related to overexpression of exosomal miR-146a-5p in medication-free patients with major depressive disorder.Psychological medicine · 2023Article
- Parsing altered gray matter morphology of depression using a framework integrating the normative model and non-negative matrix factorization.Nature communications · 2023Article
- Subthreshold depressive symptoms relate to cuneus structure: Thickness asymmetry and sex differences.Journal of psychiatric research · 2022Article
Corrections and comments
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Authors and funding
7 authors.
Funding
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Abstract
Previous structural imaging studies have found evidence of brain morphometric changes in patients with major depressive disorder (MDD), but these studies rarely excluded compounding effects of certain important factors, such as medications and long duration of illnesses. Furthermore, the neurobiological mechanism of the macroscopic findings of structural alterations in MDD patients remains unclear. In this study, we utilized magnetization transfer imaging, a quantitative measure of the macromolecular structural integrity of brain tissue, to identify biophysical alterations, which are represented by a magnetization transfer ratio (MTR), in MDD patients. To ascertain whether MTR changes occur independent of volume loss, we also conduct voxel-based morphometry (VBM) analysis. The participants included 27 first-episode, drug-naive MDD patients and 28 healthy controls matched for age and gender. Whole-brain voxel-based analysis was used to compare MTR and gray matter volume across groups and to analyse correlations between MTR and age, symptom severity, and illness duration. The patients exhibited significantly lower MTR in the left superior parietal lobule and left middle occipital gyrus compared with healthy controls, which may be related to the attentional and cognitive dysfunction in MDD patients. The VBM analysis revealed significantly increased gray matter volume in right postcentral gyrus in MDD patients. These findings in first-episode, drug-naive MDD patients may reflect microstructural gray matter changes in the parietal and occipital cortices close to illness onset that existed before volume loss, and thus potentially provide important new insight into the early neurobiology of depression.
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