Evidence map›Paper›PMID 27824316›Full record

ArticleAging2016

Nickel chloride (NiCl2) in hepatic toxicity: apoptosis, G2/M cell cycle arrest and inflammatory response.

Hongrui Guo, Hengmin Cui, Jing Fang, Zhicai Zuo, Junliang Deng, Xun Wang, Ling Zhao, Kejie Chen, Jie Deng

Open access · hybridAbstract read
In one paragraph

Article in Aging, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.5field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 44 citations in OpenAlex.

  1. Review
  2. E-Cigarette effects on oral health: A molecular perspective.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association · 2025
    Review
  3. Article
  4. Article
  5. Pathogenesis-Related Gene Expression in Response toFrontiers in veterinary science · 2022
    Article
  6. Article
  7. Nickel carcinogenesis mechanism: cell cycle dysregulation.Environmental science and pollution research international · 2021
    Review
  8. Impact of Dietary or Drinking WaterFrontiers in veterinary science · 2021
    Article
  9. Article
  10. Nickel Carcinogenesis Mechanism: DNA Damage.International journal of molecular sciences · 2019
    Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Hongrui GuoCollege of Veterinary Medicine, Sichuan Agricultural University Ya'an 625014, China.
Hengmin CuiCollege of Veterinary Medicine, Sichuan Agricultural University Ya'an 625014, China.
Jing FangCollege of Veterinary Medicine, Sichuan Agricultural University Ya'an 625014, China.
Zhicai ZuoCollege of Veterinary Medicine, Sichuan Agricultural University Ya'an 625014, China.
Junliang DengCollege of Veterinary Medicine, Sichuan Agricultural University Ya'an 625014, China.
Xun WangCollege of Veterinary Medicine, Sichuan Agricultural University Ya'an 625014, China.
Ling ZhaoCollege of Veterinary Medicine, Sichuan Agricultural University Ya'an 625014, China.
Kejie ChenCollege of Veterinary Medicine, Sichuan Agricultural University Ya'an 625014, China.
Jie DengCollege of Veterinary Medicine, Sichuan Agricultural University Ya'an 625014, China.
Sichuan Agricultural University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Up to now, the precise mechanism of Ni toxicology is still indistinct. Our aim was to test the apoptosis, cell cycle arrest and inflammatory response mechanism induced by NiCl

Indexed as

AnimalsApoptosisApoptosis Regulatory ProteinsChickensEndoplasmic Reticulum StressG2 Phase Cell Cycle CheckpointsInflammationLiverMitochondriaNF-kappa BNickelSignal TransductionApoptosis Regulatory ProteinsNF-kappa BNickelnickel chlorideapoptosiscell cycle G2/M phase arrestinflammatory responseliverNiCl2

Identifiers

PMID27824316
PMCPMC5191883
OpenAlexW2552852593

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.