ArticleEpigenetics2016
PEG3 binds to H19-ICR as a transcriptional repressor.
Article in Epigenetics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- The imprinted Peg3 gene is a potent regulator of the DNA methylome in trophoblast cells.Stem cell reports · 2026Article
- MTTL3 upregulates microRNA-1246 to promote occurrence and progression of NSCLC via targeting paternally expressed gene 3.Molecular therapy. Nucleic acids · 2021Article
- Long noncoding RNA H19 - a new player in the pathogenesis of liver diseases.Translational research : the journal of laboratory and clinical medicine · 2021Review
- PEG3 controls lipogenesis through ACLY.PloS one · 2021Article
- Long Noncoding RNA H19: A Novel Therapeutic Target Emerging in OncologyFrontiers in cell and developmental biology · 2021Review
- Article
- Inhibition of LncRNAH19 has the effect of anti-tumour and enhancing sensitivity to Gefitinib and Chemotherapy in Non-small-cell lung cancer in vivo.Journal of cellular and molecular medicine · 2020Article
- Oxytocin receptor is regulated by Peg3.PloS one · 2018Article
- Allele and dosage specificity of the Peg3 imprinted domain.PloS one · 2018Article
- PEG3 control on the mammalian MSL complex.PloS one · 2017Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Paternally expressed gene 3 (Peg3) encodes a DNA-binding protein with 12 C2H2 zinc finger motifs. In the current study, we performed ChIP-seq using mouse embryonic fibroblast (MEF) cells. This experiment identified a set of 16 PEG3 genomic targets, the majority of which overlapped with the promoter regions of genes with oocyte expression. These potential downstream genes were upregulated in MEF cells lacking PEG3 protein, suggesting a potential repressor role for PEG3. Our study also identified the imprinting control region (ICR) of H19 as a genomic target. According to the results, PEG3 binds to a specific sequence motif located between the 3
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