SynthesisScientific reports2016
Gene-gene Interaction Analyses for Atrial Fibrillation.
Open access · goldAbstract readMeta-Analysis
In one paragraph
Synthesis in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
2.1field-weighted citation impact, top 11% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.
- Freely available genomic datasets for atrial fibrillation research: current resources and analytical pipeline.Frontiers in genetics · 2026Pooled it
- Decoding the PITX2-controlled genetic network in atrial fibrillation.JCI insight · 2022Article
- Multi-Omic Approaches to Identify Genetic Factors in Metabolic Syndrome.Comprehensive Physiology · 2021Article
- Gene-Based Testing of Interactions Using XGBoost in Genome-Wide Association Studies.Frontiers in cell and developmental biology · 2021Article
- Genetics of Atrial Fibrillation in 2020: GWAS, Genome Sequencing, Polygenic Risk, and Beyond.Circulation research · 2020Review
- Inferior Colliculus Transcriptome After Status Epilepticus in the Genetically Audiogenic Seizure-Prone Hamster GASH/Sal.Frontiers in neuroscience · 2020Article
- The Genetic Puzzle of Familial Atrial Fibrillation.Frontiers in cardiovascular medicine · 2020Review
- Atrial Fibrillation Genetics Update: Toward Clinical Implementation.Frontiers in cardiovascular medicine · 2019Review
- Article
- Genetics of atrial fibrillation: an update.Current opinion in cardiology · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
59 authors at 20 institutions in 6 countries.
Honghuang LinNational Heart Lung and Blood Institute's and Boston University's Framingham Heart Study, Framingham, MA, USA.
Martina Mueller-NurasyidInstitute of Genetic Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
Albert V SmithIcelandic Heart Association, Kopavogur, Iceland.
Dan E ArkingMcKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
John BarnardCleveland Clinic, Cleveland, OH, USA.
Traci M BartzDepartment of Biostatistics, University of Washington, Seattle, WA, USA.
Kathryn L LunettaNational Heart Lung and Blood Institute's and Boston University's Framingham Heart Study, Framingham, MA, USA.
Kurt LohmanDepartment of Biostatistical Sciences, Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Marcus E KleberVth Department of Medicine, Medical Faculty Mannheim, Heidelberg University, Theodor-Kutzer-Ufer 1-3, 68167 Mannheim, Germany.
Steven A LubitzCardiac Arrhythmia Service, Massachusetts General Hospital, Boston, MA, USA.
Bastiaan GeelhoedDepartment of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Stella TrompetDepartment of Cardiology, Leiden University Medical Center, the Netherlands.
Maartje N NiemeijerDepartment of Epidemiology, Erasmus MC - University Medical Center Rotterdam, Rotterdam, the Netherlands.
Tim KacprowskiDepartment of Functional Genomics, Interfaculty Institute for Genetics and Functional Genomics, University Medicine and Ernst-Moritz-Arndt University Greifswald, Greifswald, Germany.
Daniel I ChasmanDivision of Preventive Medicine, Brigham and Women's Hospital, Boston MA, USA.
Derek KlarinCardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA.
Moritz F SinnerDepartment of Medicine I, Ludwig-Maximilians-University Munich, Munich, Germany.
Melanie WaldenbergerDZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, Munich, Germany.
Thomas MeitingerDZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, Munich, Germany.
Tamara B HarrisNational Institute on Aging, National Institutes of Health, Bethesda, MD, USA.
Lenore J LaunerNational Institute on Aging, National Institutes of Health, Bethesda, MD, USA.
Elsayed Z SolimanEpidemiological Cardiology Research Center, Wake Forest School of Medicine, Winston Salem, NC, USA.
Lin Y ChenCardiovascular Division, Department of Medicine, University of Minnesota Medical School, Minneapolis, MN, USA.
Jonathan D SmithCleveland Clinic, Cleveland, OH, USA.
David R Van WagonerCleveland Clinic, Cleveland, OH, USA.
Jerome I RotterInstitute for Translational Genomics and Population Sciences (J.I.R.), Departments of Pediatrics and Medicine, LABioMed at Harbor-UCLA Medical Center, Torrance, CA, USA.
Bruce M PsatyCardiovascular Health Research Unit, Departments of Medicine, Epidemiology and Health Services, University of Washington, Seattle, WA, USA.
Zhijun XieSection of Computational Biomedicine, Department of Medicine, Boston University School of Medicine, Boston, MA, USA.
Audrey E HendricksNational Heart Lung and Blood Institute's and Boston University's Framingham Heart Study, Framingham, MA, USA.
Jingzhong DingDepartment of Gerontology and Geriatric Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Graciela E DelgadoVth Department of Medicine, Medical Faculty Mannheim, Heidelberg University, Theodor-Kutzer-Ufer 1-3, 68167 Mannheim, Germany.
Niek VerweijDepartment of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Pim van der HarstDepartment of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Peter W MacfarlaneInstitute of Health and Wellbeing, College of Veterinary, Medical and Life Sciences, University of Glasgow, United Kingdom.
Ian FordRobertson Center for Biostatistics, University of Glasgow, United Kingdom.
Albert HofmanDepartment of Epidemiology, Erasmus MC - University Medical Center Rotterdam, Rotterdam, the Netherlands.
André UitterlindenDepartment of Epidemiology &Internal Medicine, Erasmus MC - University Medical Center Rotterdam, Rotterdam, the Netherlands.
Jan HeeringaDepartment of Epidemiology, Erasmus MC - University Medical Center Rotterdam, Rotterdam, the Netherlands.
Oscar H FrancoDepartment of Epidemiology, Erasmus MC - University Medical Center Rotterdam, Rotterdam, the Netherlands.
Jan A KorsDepartment of Medical Informatics, Erasmus MC - University Medical Center Rotterdam, the Netherlands.
Stefan WeissDepartment of Functional Genomics, Interfaculty Institute for Genetics and Functional Genomics, University Medicine and Ernst-Moritz-Arndt University Greifswald, Greifswald, Germany.
Henry VölzkeDZHK (German Centre for Cardiovascular Research), partner site Greifswald, Greifswald, Germany.
Lynda M RoseDivision of Preventive Medicine, Brigham and Women's Hospital, Boston MA, USA.
Pradeep NatarajanHarvard Medical School, Boston, MA, USA.
Sekar KathiresanHarvard Medical School, Boston, MA, USA.
Stefan KääbDepartment of Medicine I, Ludwig-Maximilians-University Munich, Munich, Germany.
Vilmundur GudnasonIcelandic Heart Association, Kopavogur, Iceland.
Alvaro AlonsoDepartment of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA, USA.
Mina K ChungCleveland Clinic, Cleveland, OH, USA.
Susan R HeckbertGroup Health Research Institute, Group Health Cooperative, Seattle, WA, USA.
Emelia J BenjaminNational Heart Lung and Blood Institute's and Boston University's Framingham Heart Study, Framingham, MA, USA.
Yongmei LiuDepartment of Epidemiology &Prevention, Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Winfried MärzSynlab Academy, Synlab Services, GmbH P5,7, 68161 Mannheim, Germany.
Michiel RienstraDepartment of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
J Wouter JukemaDepartment of Cardiology, Leiden University Medical Center, the Netherlands.
Bruno H StrickerDepartment of Epidemiology &Internal Medicine, Erasmus MC - University Medical Center Rotterdam, Rotterdam, the Netherlands.
Marcus DörrDZHK (German Centre for Cardiovascular Research), partner site Greifswald, Greifswald, Germany.
Christine M AlbertDivision of Preventive Medicine, Brigham and Women's Hospital, Boston MA, USA.
Patrick T EllinorHarvard Medical School, Boston, MA, USA.
Erasmus MC · NLCleveland Clinic · USWake Forest University · USBrigham and Women's Hospital · USBoston University · USFramingham Heart Study · USGerman Centre for Cardiovascular Research · DEHelmholtz Zentrum München · DEIcelandic Heart Association · ISLeiden University Medical Center · NLLudwig-Maximilians-Universität München · DEMassachusetts General Hospital · USUniversität Greifswald · DEUniversity Hospital Heidelberg · DEUniversity Medical Center Groningen · NLUniversity of Glasgow · GBUniversity of Groningen · NLBroad Institute · USCenter for Human Genetics · USEmory University · US
Funding
Institute for Clinical and Translational Research (UL1)UL1RR025005 · NCRR · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2007 to 2011
$75.8MUCLA Clinical and Translational Science InstituteUL1TR000124 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2012 to 2015
$57.0MCTSA INFRASTRUCTURE FOR PEDIATRIC RESEARCHUL1RR024989 · NCRR · CASE WESTERN RESERVE UNIVERSITY · PI DAVIS, PAMELA B · 2007 to 2011
$53.7MClinical and Translational Science Collaborative of ClevelandUL1TR000439 · NCATS · CASE WESTERN RESERVE UNIVERSITY · PI KONSTAN, MICHAEL W. · 2012 to 2016
$50.0MTransgenic & Knock-out MouseP30DK063491 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI PETER J TONTONOZ · 2003 to 2026
$40.4MPHARMACOGENOMICS OF ARRHYTHMIA THERAPYU01HL065962 · NHLBI · VANDERBILT UNIVERSITY · PI RODEN, DAN M · 2001 to 2009
$24.8MGenome-Wide Association Analysis in Essential Hypertension (FEHGAS study)R01HL086694 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI ARAVINDA CHAKRAVARTI · 2007 to 2026
$21.2MIDENTIFICATION OF COMMON GENETIC VARIANTS FOR ATRIAL FIBRILLATION AND PR INTERVALR01HL092577 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI BENJAMIN, EMELIA J., ELLINOR, PATRICK THOMAS · 2009 to 2025
$20.6MPharmacogenomics of Arrhythmia TherapyU19HL065962 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI RODEN, DAN M · 2010 to 2014
$17.4MMULTIDISCIPLINARY RESEARCH TRAINING IN CARDIOLOGYT32HL007208 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI Patrick Thomas Ellinor, David E Sosnovik · 1985 to 2026
$16.1MEpidemiology of Venous Thrombosis & Pulmonary EmbolismR01HL059367 · NHLBI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI TANG, WEIHONG · 1998 to 2024
$11.8MHARVARD-LONGWOOD RESEARCH TRAINING IN VASCULAR SURGERYT32HL007734 · NHLBI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI FERRAN, CHRISTIANE, LOGERFO, FRANK W · 1993 to 2023
$10.5MNCRR NIH HHS UL1 RR024989NCRR NIH HHS UL1 RR025005NHGRI NIH HHS U01 HG004402NHLBI NIH HHS HHSN268200800007CNHLBI NIH HHS HHSN268201100005CNHLBI NIH HHS HHSN268201100005GNHLBI NIH HHS HHSN268201100005INHLBI NIH HHS HHSN268201100006CNHLBI NIH HHS HHSN268201100007CNHLBI NIH HHS HHSN268201100007INHLBI NIH HHS HHSN268201100008CNHLBI NIH HHS HHSN268201100008INHLBI NIH HHS HHSN268201100009CNHLBI NIH HHS HHSN268201100009INHLBI NIH HHS HHSN268201100010CNHLBI NIH HHS HHSN268201100011CNHLBI NIH HHS HHSN268201100011INHLBI NIH HHS HHSN268201100012CNHLBI NIH HHS HHSN268201200036CNHLBI NIH HHS HHSN268201500001CNHLBI NIH HHS HHSN268201500001INHLBI NIH HHS K23 HL114724NHLBI NIH HHS K24 HL105780NHLBI NIH HHS N01 HC015103NHLBI NIH HHS N01 HC025195NHLBI NIH HHS N01 HC035129NHLBI NIH HHS N01 HC045133NHLBI NIH HHS N01 HC055222NHLBI NIH HHS N01 HC075150NHLBI NIH HHS N01 HC085079NHLBI NIH HHS N01 HC085080NHLBI NIH HHS N01 HC085081NHLBI NIH HHS N01 HC085082NHLBI NIH HHS N01 HC085083NHLBI NIH HHS N01 HC085084NHLBI NIH HHS N01 HC085085NHLBI NIH HHS N01 HC085086NHLBI NIH HHS R01 HL059367NHLBI NIH HHS R01 HL080295NHLBI NIH HHS R01 HL086694NHLBI NIH HHS R01 HL087641NHLBI NIH HHS R01 HL087652NHLBI NIH HHS R01 HL090620NHLBI NIH HHS R01 HL092577NHLBI NIH HHS R01 HL103612NHLBI NIH HHS R01 HL104156NHLBI NIH HHS R01 HL105756NHLBI NIH HHS R01 HL111314NHLBI NIH HHS R01 HL120393NHLBI NIH HHS R01 HL128914NHLBI NIH HHS U01 HL065962NHLBI NIH HHS U01 HL080295NHLBI NIH HHS U01 HL120393NHLBI NIH HHS U19 HL065962NIA NIH HHS R01 AG015928NIA NIH HHS R01 AG020098NIA NIH HHS R01 AG023629NIA NIH HHS R01 AG027058NIA NIH HHS R56 AG020098NIA NIH HHS R56 AG023629NLM NIH HHS R01 LM010098
Abstract
Atrial fibrillation (AF) is a heritable disease that affects more than thirty million individuals worldwide. Extensive efforts have been devoted to the study of genetic determinants of AF. The objective of our study is to examine the effect of gene-gene interaction on AF susceptibility. We performed a large-scale association analysis of gene-gene interactions with AF in 8,173 AF cases, and 65,237 AF-free referents collected from 15 studies for discovery. We examined putative interactions between genome-wide SNPs and 17 known AF-related SNPs. The top interactions were then tested for association in an independent cohort for replication, which included more than 2,363 AF cases and 114,746 AF-free referents. One interaction, between rs7164883 at the HCN4 locus and rs4980345 at the SLC28A1 locus, was found to be significantly associated with AF in the discovery cohorts (interaction OR = 1.44, 95% CI: 1.27-1.65, P = 4.3 × 10
Indexed as
Genetic Association StudiesAgedAtrial FibrillationCohort StudiesEpistasis, GeneticFemaleGenetic Predisposition to DiseaseGenome-Wide Association StudyGenotypeHumansHyperpolarization-Activated Cyclic Nucleotide-Gated ChannelsMaleMembrane Transport ProteinsMiddle AgedMultivariate AnalysisMuscle Proteinscif nucleoside transporterHCN4 protein, humanHyperpolarization-Activated Cyclic Nucleotide-Gated ChannelsMembrane Transport ProteinsMuscle ProteinsPotassium Channels
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.