ArticleScientific reports2016
A Comprehensive Characterization of the Function of LincRNAs in Transcriptional Regulation Through Long-Range Chromatin Interactions.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 24 citations in OpenAlex.
- Simultaneous profiling of chromatin-associated RNA at targeted DNA loci and RNA-RNA Interactions through TaDRIM-seq.Nature communications · 2025Article
- The regulatory activities of MALAT1 in the development of bone and cartilage diseases.Frontiers in endocrinology · 2022Review
- Targeting the Expression of Long Noncoding RNAs in Murine Satellite Cells from Single Myofibers.Bio-protocol · 2021Article
- Non-Coding Variants in Cancer: Mechanistic Insights and Clinical Potential for Personalized Medicine.Non-coding RNA · 2021Review
- Wnt-regulated lncRNA discovery enhanced by in vivo identification and CRISPRi functional validation.Genome medicine · 2020Article
- Small RNAs, Big Diseases.International journal of molecular sciences · 2020Review
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- Identifying lncRNA-mediated regulatory modules via ChIA-PET network analysis.BMC bioinformatics · 2019Article
- LncRNAs in TGF-β-Driven Tissue Fibrosis.Non-coding RNA · 2018Review
- CisPi: a transcriptomic score for disclosing cis-acting disease-associated lincRNAs.Bioinformatics (Oxford, England) · 2018Article
- Into the Wild: GWAS Exploration of Non-coding RNAs.Frontiers in cardiovascular medicine · 2018Review
- Genome-Wide Association and Replication Study of Hepatotoxicity Induced by Antiretrovirals Alone or with Concomitant Anti-Tuberculosis Drugs.Omics : a journal of integrative biology · 2017Article
- Non-coding RNAs in skeletal muscle regeneration.Non-coding RNA research · 2017Review
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
LincRNAs are emerging as important regulators with various cellular functions. However, the mechanisms behind their role in transcriptional regulation have not yet been fully explored. In this report, we proposed to characterize the diverse functions of lincRNAs in transcription regulation through an examination of their long-range chromatin interactions. We found that the promoter regions of lincRNAs displayed two distinct patterns of chromatin states, promoter-like and enhancer-like, indicating different regulatory functions for lincRNAs. Notably, the chromatin interactions between lincRNA genes and other genes suggested a potential mechanism for lincRNAs in the regulation of other genes at the RNA level because the transcribed lincRNAs could function at local spaces on other genes that interact with the lincRNAs at the DNA level. These results represent a novel way to predict the functions of lincRNAs. The GWAS-identification of SNPs within the lincRNAs revealed that some lincRNAs were disease-associated, and the chromatin interactions with those lincRNAs suggested that they were potential target genes of these lincRNA-associated SNPs. Our study provides new insights into the roles that lincRNAs play in transcription regulation.
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