ArticleScientific reports2016
Thymic exosomes promote the final maturation of thymocytes.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Dysregulation of the Bone Marrow Microenvironment in Pediatric Tumors: The Role of Extracellular Vesicles in Acute Leukemias and Neuroblastoma.International journal of molecular sciences · 2025Review
- Extracellular Vesicles and Immune System Function: Exploring Novel Approaches to Colorectal Cancer Immunotherapy.Biomedicines · 2024Review
- The 'communicatome' of pregnancy: spotlight on cellular and extravesicular chimerism.EMBO molecular medicine · 2024Review
- TCTP regulates genotoxic stress and tumorigenicity via intercellular vesicular signaling.EMBO reports · 2024Article
- Extracellular vesicles: an emerging tool for wild immunology.Discovery immunology · 2024Review
- Food-Derived Extracellular Vesicles as Multi-Bioactive Complex and Their Versatile Health Effects.Antioxidants (Basel, Switzerland) · 2023Review
- Extracellular Vesicles as a Translational Approach for the Treatment of COVID-19 Disease: An Updated Overview.Viruses · 2023Review
- The roles of extracellular vesicles in the immune system.Nature reviews. Immunology · 2023Review
- Complex interactions of cellular players in chronic Graft-versus-Host Disease.Frontiers in immunology · 2023Review
- Extracellular Vesicles as Novel Drug-Delivery Systems through Intracellular Communications.Membranes · 2022Review
- Insight into Extracellular Vesicle-Cell Communication: From Cell Recognition to Intracellular Fate.Cells · 2022Review
- Epigenetic modifications in thymic epithelial cells: an evolutionary perspective for thymus atrophy.Clinical epigenetics · 2021Review
- Exosome-Derived MicroRNAs of Human Milk and Their Effects on Infant Health and Development.Biomolecules · 2021Review
- Exosomes of pasteurized milk: potential pathogens of Western diseases.Journal of translational medicine · 2019Review
- Thymic Microenvironment Is Modified by Malnutrition andFrontiers in cellular and infection microbiology · 2019Article
- Transgenic Exosomes for Thymus Regeneration.Frontiers in immunology · 2019Article
- Protein Kinase C δ Regulates the Depletion of Actin at the Immunological Synapse Required for Polarized Exosome Secretion by T Cells.Frontiers in immunology · 2019Article
- Imaging Polarized Secretory Traffic at the Immune Synapse in Living T Lymphocytes.Frontiers in immunology · 2018Review
- The major histocompatibility complex class I immunopeptidome of extracellular vesicles.The Journal of biological chemistry · 2017Article
- PPARgamma Deficiency Counteracts Thymic Senescence.Frontiers in immunology · 2017Article
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Extensive knowledge has been gained the last years concerning mechanisms underlying the selection of single positive thymocytes in the thymic medulla. Less is known regarding other important processes in the thymic medulla such as the regulation of late stage thymocyte maturation. We have previously reported that exosomes are abundant in the thymus with a phenotype that indicates an epithelial cell origin and immunoregulatory properties. In this study we use an in vitro system to investigate the effects of thymic exosomes on the maturation of single positive thymocytes as well as effects on nTreg formation. We show that thymic exosomes promote the maturation of single positive CD4
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