Evidence map›Paper›PMID 27824033›Full record

ArticleNature communications2016

Promotion of behavior and neuronal function by reactive oxygen species in C. elegans.

Guang Li, Jianke Gong, Haoyun Lei, Jianfeng Liu, X Z Shawn Xu

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
2.6field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 71 citations in OpenAlex.

  1. Article
  2. A lateralized sensory signaling pathway mediates context-dependent olfactory plasticity inProceedings of the National Academy of Sciences of the United States of America · 2026
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  7. UNC-49 is a redox-sensitive GABAScience advances · 2023
    Article
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  19. Article
  20. SIRT1 Promotes M2 Microglia PolarizationFrontiers in immunology · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Guang LiCollege of Life Science and Technology, Collective Innovation Center for Brain Science and Key Laboratory of Molecular Biophysics of MOE, Huazhong University of Science and Technology, Wuhan, Hubei 430074, China.
Jianke GongCollege of Life Science and Technology, Collective Innovation Center for Brain Science and Key Laboratory of Molecular Biophysics of MOE, Huazhong University of Science and Technology, Wuhan, Hubei 430074, China.
Haoyun LeiCollege of Life Science and Technology, Collective Innovation Center for Brain Science and Key Laboratory of Molecular Biophysics of MOE, Huazhong University of Science and Technology, Wuhan, Hubei 430074, China.
Jianfeng LiuCollege of Life Science and Technology, Collective Innovation Center for Brain Science and Key Laboratory of Molecular Biophysics of MOE, Huazhong University of Science and Technology, Wuhan, Hubei 430074, China.
X Z Shawn XuLife Sciences Institute, University of Michigan, Ann Arbor, Michigan 48109, USA.
University of Michigan–Ann Arbor · USHuazhong University of Science and Technology · CN

Funding

VIVARIUM MODULEP30EY007003 · NEI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI David Antonetti · 1987 to 2026
$17.6M
Neural circuits and synaptic mechanisms underlying behavior in C. elegansR01GM083241 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI XU, SHAWN · 2008 to 2017
$3.4M
NEI NIH HHS P30 EY007003NIGMS NIH HHS R01 GM083241
6 · The paper itself

Abstract

Reactive oxygen species (ROS) are well known to elicit a plethora of detrimental effects on cellular functions by causing damages to proteins, lipids and nucleic acids. Neurons are particularly vulnerable to ROS, and nearly all forms of neurodegenerative diseases are associated with oxidative stress. Here, we report the surprising finding that exposing C. elegans to low doses of H

Indexed as

Behavior, AnimalAnimalsAvoidance LearningCaenorhabditis elegansCaenorhabditis elegans ProteinsHydrogen PeroxideMAP Kinase Signaling SystemMitogen-Activated Protein KinasesNerve Tissue ProteinsNeuronsOsmosisPeroxiredoxinsPhosphorylationPhosphothreonineProto-Oncogene Proteins c-aktReactive Oxygen Speciesakt-1 protein, C elegansCaenorhabditis elegans ProteinsHydrogen PeroxideMitogen-Activated Protein KinasesNerve Tissue ProteinsOSM-9 protein, C elegansPeroxiredoxinsPhosphothreoninePmk-1 protein, C elegansProto-Oncogene Proteins c-aktReactive Oxygen SpeciesTRPV Cation Channels

Identifiers

PMID27824033
PMCPMC5105148
OpenAlexW2556894624

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.