ArticleOncotarget2017
Dosimetric superiority of flattening filter free beams for single-fraction stereotactic radiosurgery in single brain metastasis.
Article in Oncotarget, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.
- Pooled it
- Artificial intelligence-based motion tracking in cancer radiotherapy: A review.Journal of applied clinical medical physics · 2024Review
- Commissioning and clinical evaluation of a novel high-resolution quality assurance digital detector array for SRS and SBRT.Journal of applied clinical medical physics · 2024Article
- Evaluation of Patient-Specific Quality Assurance in Single Isocenter Multitarget Stereotactic Radiosurgery of Brain Metastases Using Octavius 4D for Flattening Filter Free Beams.Asian Pacific journal of cancer prevention : APJCP · 2023Article
- Article
- Planar EPID-Based Dosimetry for SRS and SRT Patient-Specific QA.Life (Basel, Switzerland) · 2021Article
- Dosimetric quality and delivery efficiency of robotic radiosurgery for brain metastases: Comparison with C-arm linear accelerator based plans.Journal of applied clinical medical physics · 2019Article
- Dosimetric performance of two linear accelerator-based radiosurgery systems to treat single and multiplebrain metastases.The British journal of radiology · 2019Article
- Stereotactic ablative radiation therapy for brain metastases with volumetric modulated arc therapy and flattening filter free delivery: feasibility and early clinical results.La Radiologia medica · 2017Article
- Normal Tissue Objective Parameter Optimization in Eclipse Treatment Planning System: Enhancing Stereotactic Radiosurgery Quality with Noncoplanar RapidArc versus HyperArc Plans.Journal of medical physicsArticle
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
For single-fraction stereotactic radiosurgery (SRS) using linac in brain metastases, more accurate treatment delivery with higher tumor absorbed doses and lower absorbed doses to normal tissues remains an enormous challenge. The purpose of this study was to investigate the dosimetric superiority in flattening filter free beams (FFF) for volumetric modulated arc therapy (VMAT) in single brain metastasis. 68 patients with single brain metastasis were included in this study. Every patient was subjected to VMAT treatment plans using 6 MV standard flattened (FF) beams (VMAT_FF) and 6 MV FFF beams (VMAT_FFF) with single fraction doses of 20 Gy. Dosimetric evaluation was performed by analysis of target coverage, dose gradients, beam-on time (BOT), gantry speed and number of monitor units (MU). There were no differences between VMAT_FF and VMAT_FFF plans in conformity and MU. VMAT_FFF plans showed obvious superiority in homogeneity, dose gradients and efficiency. For the mean BOT, VMAT_FFF plans provided a significant decrease by 42.8% compared with VMAT_FF. By the use of FFF beams, brain irradiation was minimized with about 2% reductions in low-dose regions (about 5-10 Gy). FFF beams not only resulted in more efficiency by reducing treatment time, but also provided further brain sparing compared to traditional techniques for SRS in single brain metastasis.
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