Evidence map›Paper›PMID 27823981›Full record

Trial reportOncotarget2017

Repetitive transcranial magnetic stimulation improves cognitive function of Alzheimer's disease patients.

Junwu Zhao, Zhenguang Li, Yannan Cong, Jinbiao Zhang, Ming Tan, Haixia Zhang, Na Geng, Mengfan Li, Wenwen Yu, Peiyan Shan

Registry-linked trialOpen access · diamondAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Oncotarget, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04866979 (StimoLaMente - La Stimolazione Cerebrale Non Invasiva Applicata Alla Riabilitazione Della Malattia di Alzheimer/ StimoLaMente - Applying Non-invasive Brain Stimulation in Alzheimer's Rehabilitation), which is not on this map. Cited by 78 papers, 20 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
78citing papers in PubMed, 20 pooled it
3.1field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04866979 naunknown statusnot on this mapstarted 2021, after this paper: background citation

StimoLaMente - La Stimolazione Cerebrale Non Invasiva Applicata Alla Riabilitazione Della Malattia di Alzheimer/ StimoLaMente - Applying Non-invasive Brain Stimulation in Alzheimer's Rehabilitation

TypeinterventionalSponsorUniversità degli Studi di TrentoRan2021 to 2024Enrolled200ConditionsAlzheimer Disease, Mild Cognitive ImpairmentArmsExperimental: Continuous TBS (cTBS), Intermittent TBS (iTBS), Cognitive training (CT)., Sham Stimulation (shamTBS)
3 · Its place in the literature

Who cites it

78 citing papers in PubMed, 20 syntheses or guidelines pooled it, 147 citations in OpenAlex.

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  5. Repetitive transcranial magnetic stimulation for cognitive and emotional symptoms in neurodegenerative diseases: a systematic review and dose-response meta-analysis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025
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  9. Systematic review and meta-analysis of repetitive transcranial magnetic stimulation (rTMS) for activities of daily living in Alzheimer's disease.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025
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  17. The role of noninvasive brain stimulation for behavioral and psychological symptoms of dementia: a systematic review and meta-analysis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2020
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18 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Junwu ZhaoDepartment of Neurology, Qilu Hospital of Shandong University, Jinan, Shandong, China.
Zhenguang LiDepartment of Neurology, Weihai Municipal Hospital, Weihai, Shandong, China.
Yannan CongDepartment of Neurology, Weihai Municipal Hospital, Weihai, Shandong, China.
Jinbiao ZhangDepartment of Neurology, Weihai Municipal Hospital, Weihai, Shandong, China.
Ming TanDepartment of Neurology, Weihai Municipal Hospital, Weihai, Shandong, China.
Haixia ZhangDepartment of Neurology, Weihai Municipal Hospital, Weihai, Shandong, China.
Na GengDepartment of Neurology, Weihai Municipal Hospital, Weihai, Shandong, China.
Mengfan LiDepartment of Neurology, Weihai Municipal Hospital, Weihai, Shandong, China.
Wenwen YuDepartment of Clinical Medicine (Neurology), Weifang Medical University, Weifang, Shandong, China.
Peiyan ShanDepartment of Neurology, Qilu Hospital of Shandong University, Jinan, Shandong, China.
Weihai Municipal Hospital · CNQilu Hospital of Shandong University · CNWeifang Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Repetitive transcranial magnetic stimulation (rTMS) acts as a kind of widely-applied and non-invasive method in the intervention of some neurological disorders. This prospective, randomized, double-blind, placebo-controlled trial investigates the effect of rTMS on 30 cases of Alzheimer's disease (AD) participants, who were classified into mild and moderate groups. Neuropsychological tests were carried out using the AD Assessment Scale-cognitive subscale (ADAS-cog), Mini-Mental State Examination (MMSE), Montreal Cognitive Assessment (MoCA), and World Health Organization University of California-Los Angeles, Auditory Verbal Learning Test (WHO-UCLA AVLT) before, immediately after, and 6 weeks after the intervention. In this work, data from 30 AD patients revealed that there was no obvious interaction effect of time-by-group. The ADAS-cog, MMSE and WHO-UCLA AVLT score in the rTMS group was significantly improved compared with baselines at 6 weeks after treatment (all p<0.05). Meanwhile, MoCA scores were also obviously ameliorated in the mild AD patients with rTMS. Besides, subgroup analysis showed that the effect of rTMS on the memory and language of mild AD patients was superior to those of moderate AD patients. In conclusion, our findings suggested that repetitive transcranial magnetic stimulation improves cognitive function, memory and language level of AD patients, especially in the mild stage of AD. Thus, rTMS can be recommended as a promising adjuvant therapy combined with cholinesterase inhibitors at the mild stage of AD patients.

Indexed as

CognitionTranscranial Magnetic StimulationAgedAlzheimer DiseaseCholinesterase InhibitorsCombined Modality TherapyFemaleHumansMaleMiddle AgedSeverity of Illness IndexTreatment OutcomeCholinesterase InhibitorsADcognitive functionrTMS

Identifiers

PMID27823981
PMCPMC5464918
OpenAlexW2549322243

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.