ArticleGeneral and comparative endocrinology2017
Prediction of a neuropeptidome for the eyestalk ganglia of the lobster Homarus americanus using a tissue-specific de novo assembled transcriptome.
Article in General and comparative endocrinology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- Neuropeptide Diversity Encoded in Newly Sequenced Crustacean Genomes Reveals Signaling Roles during Feeding.ACS chemical neuroscience · 2026Article
- Neuropeptidomics of the American LobsterJournal of proteome research · 2024Article
- Structural variation between neuropeptide isoforms affects function in the lobster cardiac system.General and comparative endocrinology · 2022Article
- Comparative Transcriptome Analysis on the Regulatory Mechanism of Thoracic Ganglia inLife (Basel, Switzerland) · 2022Article
- Isoforms of the neuropeptide myosuppressin differentially modulate the cardiac neuromuscular system of the American lobster,Journal of neurophysiology · 2022Article
- Does Differential Receptor Distribution Underlie Variable Responses to a Neuropeptide in the Lobster Cardiac System?International journal of molecular sciences · 2021Article
- Identification of Low Molecular Weight Proteins and Peptides fromBiomolecules · 2021Article
- Article
- Multiple transcriptome mining coupled with tissue specific molecular cloning and mass spectrometry provide insights into agatoxin-like peptide conservation in decapod crustaceans.General and comparative endocrinology · 2020Article
- Cloning of the first cDNA encoding a putative CCRFamide precursor: identification of the brain, eyestalk ganglia, and cardiac ganglion as sites of CCRFamide expression in the American lobster, Homarus americanus.Invertebrate neuroscience : IN · 2020Article
- Differential neuropeptide modulation of premotor and motor neurons in the lobster cardiac ganglion.Journal of neurophysiology · 2020Article
- Article
- Assessment and comparison of putative amine receptor complement/diversity in the brain and eyestalk ganglia of the lobster, Homarus americanus.Invertebrate neuroscience : IN · 2020Article
- In silico analyses suggest the cardiac ganglion of the lobster, Homarus americanus, contains a diverse array of putative innexin/innexin-like proteins, including both known and novel members of this protein family.Invertebrate neuroscience : IN · 2020Article
- Identification of the molecular components of a putative Jasus edwardsii (Crustacea; Decapoda; Achelata) circadian signaling system.Invertebrate neuroscience : IN · 2020Article
- Identification of putative neuropeptidergic signaling systems in the spiny lobster, Panulirus argus.Invertebrate neuroscience : IN · 2020Article
- Pigment Dispersing Factors and Their Cognate Receptors in a Crustacean Model, With New Insights Into Distinct Neurons and Their Functions.Frontiers in neuroscience · 2020Article
- The Crustacean Hyperglycemic Hormone Superfamily: Progress Made in the Past Decade.Frontiers in endocrinology · 2020Review
- To what extent may peptide receptor gene diversity/complement contribute to functional flexibility in a simple pattern-generating neural network?Comparative biochemistry and physiology. Part D, Genomics & proteomics · 2019Article
- RNAi mediated myosuppressin deficiency affects muscle development and survival in the salmon louse (Lepeophtheirus salmonis).Scientific reports · 2019Article
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Abstract
In silico transcriptome mining is a powerful tool for crustacean peptidome prediction. Using homology-based BLAST searches and a simple bioinformatics workflow, large peptidomes have recently been predicted for a variety of crustaceans, including the lobster, Homarus americanus. Interestingly, no in silico studies have been conducted on the eyestalk ganglia (lamina ganglionaris, medulla externa, medulla interna and medulla terminalis) of the lobster, although the eyestalk is the location of a major neuroendocrine complex, i.e., the X-organ-sinus gland system. Here, an H. americanus eyestalk ganglia-specific transcriptome was produced using the de novo assembler Trinity. This transcriptome was generated from 130,973,220 Illumina reads and consists of 147,542 unique contigs. Eighty-nine neuropeptide-encoding transcripts were identified from this dataset, allowing for the deduction of 62 distinct pre/preprohormones. Two hundred sixty-two neuropeptides were predicted from this set of precursors; the peptides include members of the adipokinetic hormone-corazonin-like peptide, allatostatin A, allatostatin B, allatostatin C, bursicon α, CCHamide, corazonin, crustacean cardioactive peptide, crustacean hyperglycemic hormone (CHH), CHH precursor-related peptide, diuretic hormone 31, diuretic hormone 44, eclosion hormone, elevenin, FMRFamide-like peptide, glycoprotein hormone α2, glycoprotein hormone β5, GSEFLamide, intocin, leucokinin, molt-inhibiting hormone, myosuppressin, neuroparsin, neuropeptide F, orcokinin, orcomyotropin, pigment dispersing hormone, proctolin, pyrokinin, red pigment concentrating hormone, RYamide, short neuropeptide F, SIFamide, sulfakinin, tachykinin-related peptide and trissin families. The predicted peptides expand the H. americanus eyestalk ganglia neuropeptidome approximately 7-fold, and include 78 peptides new to the lobster. The transcriptome and predicted neuropeptidome described here provide new resources for investigating peptidergic signaling within/from the lobster eyestalk ganglia.
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