ArticleJournal of Korean medical science2016
Impact of Young Age at Diagnosis on Survival in Patients with Surgically Treated Renal Cell Carcinoma: a Multicenter Study.
Article in Journal of Korean medical science, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- The Construction and Validation of a new Predictive Model for Overall Survival of Clear Cell Renal Cell Carcinoma Patients with Bone Metastasis Based on Machine Learning Algorithm.Technology in cancer research & treatmentTrial
- Clinicopathologic features and survival disparities in early onset clear cell renal cell carcinoma in Texas.Proceedings (Baylor University. Medical Center) · 2026Article
- Accelerated hazard prediction based on age time-scale for women diagnosed with breast cancer using a deep learning method.BMC medical informatics and decision making · 2024Article
- Retrospective Multicenter Analysis of Prognostic Risk Factors for One Year Recurrence in Patient With Renal Cell Carcinoma After Partial or Radical Nephrectomy: Results of Korean Renal Cancer Study Group (KRoCS) Database.Journal of Korean medical science · 2024Article
- Prognosis of clear cell renal cell carcinoma patients stratified by age: A research relied on SEER database.Frontiers in oncology · 2022Article
- 53 years old is a reasonable cut-off value to define young and old patients in clear cell renal cell carcinoma: a study based on TCGA and SEER database.BMC cancer · 2021Article
- Broussochalcone A Induces Apoptosis in Human Renal Cancer Cells via ROS Level Elevation and Activation of FOXO3 Signaling Pathway.Oxidative medicine and cellular longevity · 2021Article
- Bone Metastasis in Renal Cell Carcinoma Patients: Risk and Prognostic Factors and Nomograms.Journal of oncology · 2021Article
- A Retrospective, Multicenter, Long-Term Follow-Up Analysis of the Prognostic Characteristics of Recurring Non-Metastatic Renal Cell Carcinoma After Partial or Radical Nephrectomy.Frontiers in oncology · 2021Article
- The prognostic role of preoperative serum albumin/globulin ratio in patients with non-metastatic renal cell carcinoma undergoing partial or radical nephrectomy.Scientific reports · 2020Article
- The age-adjusted Charlson comorbidity index as a predictor of overall survival of surgically treated non-metastatic clear cell renal cell carcinoma.Journal of cancer research and clinical oncology · 2020Article
- Development and Validation of a Nomogram Predicting the Prognosis of Renal Cell Carcinoma After Nephrectomy.Cancer management and research · 2020Article
- Surgical treatment for Xp11.2 translocation renal cell carcinoma with venous thrombus: A STROBE-compliant study.Medicine · 2019Article
- Trends in clinical, operative, and pathologic characteristics of surgically treated renal mass in a Korean center: A surgical series from 1988 through 2015.Investigative and clinical urology · 2019Article
- Clinicopathological Features and Survival Data of Localized Renal Masses in Young AdultsAsian Pacific journal of cancer prevention : APJCP · 2018Article
- Disparities of age-based cancer-specific survival improvement with various clinicopathologic characteristics for kidney cancer.Cancer management and research · 2018Article
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Abstract
The prognostic significance of age in renal cell carcinoma (RCC) is a subject of debate. The aim of the present multi-institutional study was to evaluate the impact of age on clinicopathological features and survival in a large cohort of patients with RCC. A total of 5,178 patients who underwent surgery for RCC at eight institutions in Korea between 1999 and 2011 were categorized into three groups according to age at diagnosis as follows: young age (< 40 years, n = 541), middle-age (≥ 40 and < 60 years, n = 2,551), and old age (≥ 60 years, n = 2,096) groups. Clinicopathological variables and survival rates were compared between the three groups. Young patients had lower stage tumors with a low Fuhrman grade, a lower rate of lymphovascular invasion than patients in the other age groups. Regarding histologic type, the young age group had a lower percentage of clear cell histology and a greater incidence of Xp11.2 translocation RCC. Kaplan-Meier estimates showed that cancer-specific survival was significantly better in the young age group than in the other groups (log rank test, P = 0.008). However, age at diagnosis was not an independent predictor of survival in multivariate analysis. In conclusion, young age at diagnosis was associated with favorable pathologic features, although it was not an independent prognostic factor for survival in patients with surgically-treated RCC. Age itself should not be regarded as a crucial determinant for the treatment of RCC.
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