Evidence map›Paper›PMID 27822913›Full record

ArticleNanoscale research letters2016

Graphene Oxide-Gallic Acid Nanodelivery System for Cancer Therapy.

Dena Dorniani, Bullo Saifullah, Farahnaz Barahuie, Palanisamy Arulselvan, Mohd Zobir Bin Hussein, Sharida Fakurazi, Lance J Twyman

Abstract read
In one paragraph

Article in Nanoscale research letters, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed.

  1. Bioinspired NiCoODiscover nano · 2026
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  8. Article
  9. Review
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  11. Liver cancer wars: plant-derived polyphenols strike back.Medical oncology (Northwood, London, England) · 2024
    Review
  12. Article
  13. Article
  14. Review
  15. Article
  16. Polyphenols as Potent Epigenetics Agents for Cancer.International journal of molecular sciences · 2022
    Review
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Dena DornianiDepartment of Chemistry, University of Sheffield, Dainton Building, Brook Hill, Sheffield, S3 7HF, UK.
Bullo SaifullahMaterials Synthesis and Characterization Laboratory, Institute of Advanced Technology, University Putra Malaysia, 43400, Serdang, Malaysia.
Farahnaz BarahuieMaterials Synthesis and Characterization Laboratory, Institute of Advanced Technology, University Putra Malaysia, 43400, Serdang, Malaysia.
Palanisamy ArulselvanLaboratory of Vaccines and Immunotherapeutics, Institute of Bioscience, University Putra Malaysia, 43400, Serdang, Malaysia.
Mohd Zobir Bin HusseinMaterials Synthesis and Characterization Laboratory, Institute of Advanced Technology, University Putra Malaysia, 43400, Serdang, Malaysia. mzobir@upm.edu.my.
Sharida FakuraziLaboratory of Vaccines and Immunotherapeutics, Institute of Bioscience, University Putra Malaysia, 43400, Serdang, Malaysia.
Lance J TwymanDepartment of Chemistry, University of Sheffield, Dainton Building, Brook Hill, Sheffield, S3 7HF, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Despite the technological advancement in the biomedical science, cancer remains a life-threatening disease. In this study, we designed an anticancer nanodelivery system using graphene oxide (GO) as nanocarrier for an active anticancer agent gallic acid (GA). The successful formation nanocomposite (GOGA) was characterized using XRD, FTIR, HRTEM, Raman, and UV/Vis spectroscopy. The release study shows that the release of GA from the designed anticancer nanocomposite (GOGA) occurs in a sustained manner in phosphate-buffered saline (PBS) solution at pH 7.4. In in vitro biological studies, normal fibroblast (3T3) and liver cancer cells (HepG2) were treated with different concentrations of GO, GOGA, and GA for 72 h. The GOGA nanocomposite showed the inhibitory effect to cancer cell growth without affecting normal cell growth. The results of this research are highly encouraging to go further for in vivo studies.

Indexed as

Controlled-releaseCytotoxicityDrug delivery systemsGallic acidGraphene oxide

Identifiers

PMID27822913
PMCPMC5099306

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.