Constitutive Expression of Inducible Cyclic Adenosine Monophosphate Early Repressor (ICER) in Cycling Quiescent Hematopoietic Cells: Implications for Aging Hematopoietic Stem Cells.

Steven J Greco, Ghassan Yehia, Julius A Potian, Carlos A Molina, Pranela Rameshwar

Abstract read

In one paragraph

Article in Stem cell reviews and reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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4 · The record

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5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Steven J GrecoDepartment of Medicine, Division of Hematology-Oncology, New Jersey Medical School, Rutgers School of Biomedical Health Science, Newark, NJ, 07103, USA.

Ghassan YehiaOffice of Research Advancement, Rutgers University, New Brunswick, USA.

Julius A PotianDepartment of Medicine, Division of Hematology-Oncology, New Jersey Medical School, Rutgers School of Biomedical Health Science, Newark, NJ, 07103, USA.

Carlos A MolinaDepartment of Biology and Molecular Biology, Montclair University, Montclair, NJ, USA.

Pranela RameshwarDepartment of Medicine, Division of Hematology-Oncology, New Jersey Medical School, Rutgers School of Biomedical Health Science, Newark, NJ, 07103, USA. rameshwa@njms.rutgers.edu.

Rutgers New Jersey Medical SchoolRutgers, The State University of New Jersey · USMontclair State University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Despite extensive insights on the interaction between hematopoietic stem cells (HSCs) and the supporting bone marrow (BM) stroma in hematopoietic homeostasis there remains unanswered questions on HSC regulation. We report on the mechanism by which HSCs attain cycling quiescence by addressing a role for inducible cyclic AMP early repressor (ICER). ICER negatively transcriptional regulators of cAMP activators such as CREM and CREB. These activators can be induced by hematopoietic stimulators such as cytokines. We isolated subsets of hematopoietic cells from ten healthy donors: CD34

Indexed as

Gene ExpressionADP-ribosyl Cyclase 1AgingAntigens, CD34Blotting, WesternCell CycleCell DifferentiationCells, CulturedCyclic AMP Response Element ModulatorCyclophosphamideFluorouracilHematopoietic Stem CellsHumansImmunosuppressive AgentsProto-Oncogene Proteins c-kitSignal TransductionADP-ribosyl Cyclase 1Antigens, CD34CREM protein, humanCyclic AMP Response Element ModulatorCyclophosphamideFluorouracilImmunosuppressive AgentsProto-Oncogene Proteins c-kitBone marrowCell cycleCytokinesHematopoietic stem cellInducible cAMP early repressorTranscription factors

Identifiers

PMID27822872

DOI10.1007/s12015-016-9701-5

OpenAlexW2555010762

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.