Evidence map›Paper›PMID 27822580›Full record

ArticleJournal of biomedical optics2016

Moving-source elastic wave reconstruction for high-resolution optical coherence elastography.

Bao-Yu Hsieh, Shaozhen Song, Thu-Mai Nguyen, Soon Joon Yoon, Tueng T Shen, Ruikang K Wang, Matthew O'Donnell

Open access · hybridAbstract read
In one paragraph

Article in Journal of biomedical optics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Phantoms for use in optical coherence elastography.Journal of biomedical optics · 2026
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Bao-Yu HsiehUniversity of Washington, Department of Bioengineering, 3720 15th Avenue NE, P. O. Box 355013, Seattle, Washington 98105, United StatesbChina Medical University, Department of Biomedical Imaging and Radiological Science, 91 Hsueh-Shih Road, Taichung 40402, Taiwan.
Shaozhen SongUniversity of Washington, Department of Bioengineering, 3720 15th Avenue NE, P. O. Box 355013, Seattle, Washington 98105, United States.
Thu-Mai NguyenUniversity of Washington, Department of Bioengineering, 3720 15th Avenue NE, P. O. Box 355013, Seattle, Washington 98105, United States.
Soon Joon YoonUniversity of Washington, Department of Bioengineering, 3720 15th Avenue NE, P. O. Box 355013, Seattle, Washington 98105, United States.
Tueng T ShenUniversity of Washington, Department of Bioengineering, 3720 15th Avenue NE, P. O. Box 355013, Seattle, Washington 98105, United StatescUniversity of Washington, Department of Ophthalmology, 325 9th Avenue, Seattle, Washington 98104, United States.
Ruikang K WangUniversity of Washington, Department of Bioengineering, 3720 15th Avenue NE, P. O. Box 355013, Seattle, Washington 98105, United StatescUniversity of Washington, Department of Ophthalmology, 325 9th Avenue, Seattle, Washington 98104, United States.
Matthew O'DonnellUniversity of Washington, Department of Bioengineering, 3720 15th Avenue NE, P. O. Box 355013, Seattle, Washington 98105, United States.
University of Washington · USChina Medical University · TW

Funding

q4DE: A Biomarker for Image-Guided, Post-MI Hydrogel TherapyR01HL121226 · NHLBI · YALE UNIVERSITY · PI DUNCAN, JAMES S, O'DONNELL, MATTHEW · 2014 to 2022
$6.3M
Optical coherence elastography of corneal dynamicsR01EY026532 · NEI · UNIVERSITY OF WASHINGTON · PI SHEN, TUENG T · 2016 to 2020
$2.9M
Nano-agent for photoacoustic theranostics of dialysis graft/fistula occlusionsR01HL125339 · NHLBI · UNIVERSITY OF WASHINGTON · PI POZZO, LILO D. · 2015 to 2019
$2.8M
Sensitive tumor detection with magnetomotive imagingR01CA170734 · NCI · UNIVERSITY OF WASHINGTON · PI GAO, XIAOHU · 2012 to 2015
$1.8M
Non-invasive trapping and imaging of circulating tumor cells in the peripheral vaR01EB016034 · NIBIB · UNIVERSITY OF WASHINGTON · PI O'DONNELL, MATTHEW · 2013 to 2016
$1.7M
NCI NIH HHS R01 CA170734NEI NIH HHS R01 EY026532NHLBI NIH HHS R01 HL121226NHLBI NIH HHS R01 HL125339NIBIB NIH HHS R01 EB016034
6 · The paper itself

Abstract

Optical coherence tomography (OCT)-based elasticity imaging can map soft tissue elasticity based on speckle-tracking of elastic wave propagation using highly sensitive phase measurements of OCT signals. Using a fixed elastic wave source and moving detection, current imaging sequences have difficulty in reconstructing tissue elasticity within speckle-free regions, for example, within the crystalline lens of the eye. We present a moving acoustic radiation force imaging sequence to reconstruct elastic properties within a speckle-free region by tracking elastic wave propagation from multiple laterally moving sources across the field of view. We demonstrate the proposed strategy using heterogeneous and partial speckle-free tissue-mimicking phantoms. Harder inclusions within the speckle-free region can be detected, and the contrast-to-noise ratio slightly enhanced compared to current OCE imaging sequences. The results suggest that a moving source approach may be appropriate for OCE studies within the large speckle-free regions of the crystalline lens.

Indexed as

AnimalsElasticity Imaging TechniquesElastic ModulusHaplorhiniLens, CrystallinePhantoms, ImagingTomography, Optical Coherence

Identifiers

PMID27822580
PMCPMC5995137
OpenAlexW2554654478

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.