Evidence map›Paper›PMID 27822535›Full record

ArticlemSystems

An Integrated Metabolomic and Genomic Mining Workflow To Uncover the Biosynthetic Potential of Bacteria.

Maria Maansson, Nikolaj G Vynne, Andreas Klitgaard, Jane L Nybo, Jette Melchiorsen, Don D Nguyen, Laura M Sanchez, Nadine Ziemert, Pieter C Dorrestein, Mikael R Andersen and 1 more

Abstract read
In one paragraph

Article in mSystems. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. The atypical organization of theJournal of bacteriology · 2024
    Review
  5. Review
  6. Evaluation ofFrontiers in microbiology · 2024
    Article
  7. Review
  8. Article
  9. Article
  10. Review
  11. Article
  12. Review
  13. Metabologenomics analysis ofFrontiers in microbiology · 2023
    Article
  14. Article
  15. AntarcticFrontiers in microbiology · 2022
    Article
  16. Review
  17. Review
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Maria MaanssonDepartment of Systems Biology, Technical University of Denmark, Kgs. Lyngby, Denmark.
Nikolaj G VynneDepartment of Systems Biology, Technical University of Denmark, Kgs. Lyngby, Denmark.
Andreas KlitgaardDepartment of Systems Biology, Technical University of Denmark, Kgs. Lyngby, Denmark.
Jane L NyboDepartment of Systems Biology, Technical University of Denmark, Kgs. Lyngby, Denmark.
Jette MelchiorsenDepartment of Systems Biology, Technical University of Denmark, Kgs. Lyngby, Denmark.
Don D NguyenDepartment of Chemistry and Biochemistry, University of California San Diego, La Jolla, California, USA.
Laura M SanchezInterfaculty Institute of Microbiology and Infection Medicine, University of Tübingen, Tübingen, Germany; Collaborative Mass Spectrometry Innovation Center, University of California at San Diego, La Jolla, California, USA.
Nadine ZiemertCenter for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego, La Jolla, California, USA; Interfaculty Institute of Microbiology and Infection Medicine, University of Tübingen, Tübingen, Germany.
Pieter C DorresteinCenter for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego, La Jolla, California, USA; Collaborative Mass Spectrometry Innovation Center, University of California at San Diego, La Jolla, California, USA; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California at San Diego, La Jolla, California, USA.
Mikael R AndersenDepartment of Systems Biology, Technical University of Denmark, Kgs. Lyngby, Denmark.
Lone GramDepartment of Systems Biology, Technical University of Denmark, Kgs. Lyngby, Denmark.

Funding

UCSD/SDSU IRACDAK12GM068524 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI TREJO, JOANN · 2003 to 2025
$24.4M
Experiment based genome mining of ribosomal natural productsR01GM097509 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DORRESTEIN, PIETER C, MOORE, BRADLEY S · 2012 to 2015
$1.9M
NIGMS NIH HHS K12 GM068524NIGMS NIH HHS R01 GM097509
6 · The paper itself

Abstract

Microorganisms are a rich source of bioactives; however, chemical identification is a major bottleneck. Strategies that can prioritize the most prolific microbial strains and novel compounds are of great interest. Here, we present an integrated approach to evaluate the biosynthetic richness in bacteria and mine the associated chemical diversity. Thirteen strains closely related to

Indexed as

comparative genomicsnatural productsPseudoalteromonasuntargeted metabolomics

Identifiers

PMID27822535
PMCPMC5069768

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.