ArticleeNeuro
Lhx2 Determines Odorant Receptor Expression Frequency in Mature Olfactory Sensory Neurons.
Article in eNeuro. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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Who cites it
15 citing papers in PubMed, 26 citations in OpenAlex.
- A single-cell and spatial atlas of early human olfactory development.Nature communications · 2026Article
- LHX2: a transcription factor in development, homeostasis, repair, and disease.Frontiers in cell and developmental biology · 2026Review
- A common mechanism of singular gene choice is revealed by broadly expressed odorant receptor transgenes within the olfactory epithelium.Cell reports · 2025Article
- Determinants of odorant receptor transcription and gene choice.Chemical senses · 2025Review
- Pseudotime analysis reveals novel regulatory factors for multigenic onset and monogenic transition of odorant receptor expression.Scientific reports · 2022Article
- Homeobox genes and the specification of neuronal identity.Nature reviews. Neuroscience · 2021Review
- In silico analysis of the transcriptional regulatory logic of neuronal identity specification throughout theeLife · 2021Article
- Olfactory expression of trace amine-associated receptors requires cooperative cis-acting enhancers.Nature communications · 2021Article
- Genetic Background Effects on the Expression of an Odorant Receptor Gene.Frontiers in cellular neuroscience · 2021Article
- Inhibitory signaling in mammalian olfactory transduction potentially mediated by GαMolecular and cellular neurosciences · 2021Article
- Maturation of the Olfactory Sensory Neuron and Its Cilia.Chemical senses · 2020Review
- Commensal Bacteria Regulate Gene Expression and Differentiation in Vertebrate Olfactory Systems Through Transcription Factor REST.Chemical senses · 2019Article
- Olfactory receptor genes make the case for inter-chromosomal interactions.Current opinion in genetics & development · 2019Review
- Cooperative interactions enable singular olfactory receptor expression in mouse olfactory neurons.eLife · 2017Article
- Regulatory Features for Odorant Receptor Genes in the Mouse Genome.Frontiers in genetics · 2017Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
A developmental program of epigenetic repression prepares each mammalian olfactory sensory neuron (OSN) to strongly express one allele from just one of hundreds of odorant receptor (OR) genes, but what completes this process of OR gene choice by driving the expression of this allele is incompletely understood. Conditional deletion experiments in mice demonstrate that Lhx2 is necessary for normal expression frequencies of nearly all ORs and all trace amine-associated receptors, irrespective of whether the deletion of
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.