Evidence map›Paper›PMID 27822499›Full record

ArticleeNeuro

Acute Axonal Degeneration Drives Development of Cognitive, Motor, and Visual Deficits after Blast-Mediated Traumatic Brain Injury in Mice.

Terry C Yin, Jaymie R Voorhees, Rachel M Genova, Kevin C Davis, Ashley M Madison, Jeremiah K Britt, Coral J Cintrón-Pérez, Latisha McDaniel, Matthew M Harper, Andrew A Pieper

Open access · goldAbstract read
In one paragraph

Article in eNeuro. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed
5.2field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

50 citing papers in PubMed, 69 citations in OpenAlex.

  1. Endothelial KLF4 depletion drives age-related neurovascular dysfunction and neuropsychiatric impairment.Proceedings of the National Academy of Sciences of the United States of America · 2026
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  3. Network-based prediction and real-world patient data observation identify doxycycline as a repurposable drug in Alzheimer's disease.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2026
    Article
  4. Inhibiting 15-PGDH blocks blood-brain barrier deterioration and protects mice from Alzheimer's disease and traumatic brain injury.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  5. Article
  6. Review
  7. Article
  8. Article
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  10. Application of P7C3 Compounds to Investigating and Treating Acute and Chronic Traumatic Brain Injury.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2023
    Review
  11. Article
  12. LongitudinalCell reports methods · 2023
    Article
  13. Review
  14. Article
  15. Article
  16. Review
  17. Macrophage depletion blocks congenital SARM1-dependent neuropathy.The Journal of clinical investigation · 2022
    Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Terry C YinDepartment of Psychiatry, University of Iowa Carver College of Medicine , Iowa City, IA 52242.ORCID 0000-0001-8460-1249
Jaymie R VoorheesDepartment of Psychiatry, Interdisciplinary Graduate Program in Human Toxicology, University of Iowa Carver College of Medicine , Iowa City, IA 52242.
Rachel M GenovaDepartment of Psychiatry, University of Iowa Carver College of Medicine , Iowa City, IA 52242.
Kevin C DavisDepartment of Psychiatry, University of Iowa Carver College of Medicine , Iowa City, IA 52242.ORCID 0000-0002-0258-077X
Ashley M MadisonDepartment of Psychiatry, University of Iowa Carver College of Medicine , Iowa City, IA 52242.ORCID 0000-0002-7712-6870
Jeremiah K BrittDepartment of Psychiatry, University of Iowa Carver College of Medicine , Iowa City, IA 52242.
Coral J Cintrón-PérezDepartment of Psychiatry, University of Iowa Carver College of Medicine , Iowa City, IA 52242.ORCID 0000-0003-2160-4244
Latisha McDanielDepartment of Psychiatry, University of Iowa Carver College of Medicine , Iowa City, IA 52242.
Matthew M HarperDepartment of Veteran Affairs Center for the Prevention and Treatment of Visual Loss, University of Iowa Carver College of Medicine, Iowa City, IA 52242; Department of Ophthalmology and Visual Sciences, University of Iowa Carver College of Medicine, Iowa City, IA 52242.
Andrew A PieperDepartment of Psychiatry, University of Iowa Carver College of Medicine, Iowa City, IA 52242; Department of Neurology, University of Iowa Carver College of Medicine, Iowa City, IA 52242; Department of Free Radical and Radiation Biology, University of Iowa Carver College of Medicine, Iowa City, IA 52242; Department of Veteran Affairs, University of Iowa Carver College of Medicine, Iowa City, IA 52242; Weill Cornell Autism Research Program, Weill Cornell Medicine, Cornell University, New York, NY 10065.
University of Iowa · US

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM007337 · NIGMS · UNIVERSITY OF IOWA · PI GEYER, PAMELA K., LENTZ, STEVEN R · 1985 to 2020
$15.9M
Chronic effects of blast injury: analyses of Alzheimer related pathologyI01RX000952 · VA · VETERANS HEALTH ADMINISTRATION · PI HARPER, MATTHEW M., IKONOMOVIC, MILOS D · 2014 to 2020
–
NIGMS NIH HHS T32 GM007337RRD VA I01 RX000952
6 · The paper itself

Abstract

Axonal degeneration is a prominent feature of many forms of neurodegeneration, and also an early event in blast-mediated traumatic brain injury (TBI), the signature injury of soldiers in Iraq and Afghanistan. It is not known, however, whether this axonal degeneration is what drives development of subsequent neurologic deficits after the injury. The Wallerian degeneration slow strain (

Indexed as

AnimalsAxonsBlast InjuriesBrain Injuries, TraumaticCognitionDisease Models, AnimalMaleMaze LearningMice, Mutant StrainsMotor ActivityNeuroprotectionRetinaSpatial MemoryUbiquitin-Protein LigasesVision DisordersVisual PerceptionUbe4b protein, mouseUbiquitin-Protein Ligasesaxonal degenerationneurodegenerationnicotinamide adenine dinucleotidetraumatic brain injuryWldS mouse

Identifiers

PMID27822499
PMCPMC5086797
OpenAlexW2531262582

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.