ArticleeNeuro
High-Content Genome-Wide RNAi Screen Reveals
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Article in eNeuro. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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0cells of the map it votes in
15citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
What it found
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Who cites it
15 citing papers in PubMed, 20 citations in OpenAlex.
- Smaller hippocampal tail volume is associated with plasma CCL11 levels in patients with major depressive disorder.Psychological medicine · 2025Article
- Repurposing lapatinib as a triple antagonist of chemokine receptors 3, 4, and 5.Molecular pharmacology · 2025Article
- CC Chemokine Family Members' Modulation as a Novel Approach for Treating Central Nervous System and Peripheral Nervous System Injury-A Review of Clinical and Experimental Findings.International journal of molecular sciences · 2024Review
- CCR3 Expression in Relation to Delayed Microbleeds in a Rat Model of Large Vessel Occlusion.Journal of experimental neurology · 2024Article
- Young Astrocytic Mitochondria Attenuate the Elevated Level of CCL11 in the Aged Mice, Contributing to Cognitive Function Improvement.International journal of molecular sciences · 2023Article
- Application and prospects of high-throughput screening forWorld journal of stem cells · 2022Review
- Pregnenolone Attenuates the Ischemia-Induced Neurological Deficit in the Transient Middle Cerebral Artery Occlusion Model of Rats.ACS omega · 2022Article
- Neurons and glial cells acquire a senescent signature after repeated mild traumatic brain injury in a sex-dependent manner.Frontiers in neuroscience · 2022Article
- Gut microbial dysbiosis correlates with stroke severity markers in aged rats.Frontiers in stroke · 2022Article
- Cytokine Signalling at the Microglial Penta-Partite Synapse.International journal of molecular sciences · 2021Review
- Exposure to small molecule cocktails allows induction of neural crest lineage cells from human adipose-derived mesenchymal stem cells.PloS one · 2020Article
- Pramipexole prevents ischemic cell death via mitochondrial pathways in ischemic stroke.Disease models & mechanisms · 2019Article
- Expression of Cytokines and Chemokines as Predictors of Stroke Outcomes in Acute Ischemic Stroke.Frontiers in neurology · 2019Article
- Article
- CCR3 Is Associated with the Death of a Photoreceptor Cell-line Induced by Light Exposure.Frontiers in pharmacology · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
17 authors at 2 institutions in 3 countries.
Jianmin ZhangNeuroregeneration Program, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205; Department of Immunology, Neuroscience Center, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and School of Basic Medicine, Peking Union Medical College, State Key Laboratory of Medical Molecular Biology, Beijing, 100005, China.ORCID 0000-0003-4765-0812
Huaishan WangDepartment of Immunology, Neuroscience Center, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and School of Basic Medicine, Peking Union Medical College, State Key Laboratory of Medical Molecular Biology , Beijing, 100005, China.
Omar SherbiniNeuroregeneration Program, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205.
Emily Ling-Lin PaiNeuroregeneration Program, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205.
Sung-Ung KangNeuroregeneration Program, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205.ORCID 0000-0002-8393-2588
Ji-Sun KwonNeuroregeneration Program, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205.
Jia YangDepartment of Immunology, Neuroscience Center, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and School of Basic Medicine, Peking Union Medical College, State Key Laboratory of Medical Molecular Biology , Beijing, 100005, China.ORCID 0000-0002-3992-4070
Wei HeDepartment of Immunology, Neuroscience Center, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and School of Basic Medicine, Peking Union Medical College, State Key Laboratory of Medical Molecular Biology , Beijing, 100005, China.
Hong WangSolomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine , Baltimore, MD 21205.
Stephen M EackerNeuroregeneration Program, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205.ORCID 0000-0002-9678-1192
Zhikai ChiNeuroregeneration Program, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205.
Xiaobo MaoNeuroregeneration Program, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205.ORCID 0000-0001-6587-556X
Jinchong XuNeuroregeneration Program, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205.
Haisong JiangNeuroregeneration Program, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205.
Shaida A AndrabiNeuroregeneration Program, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205.
Ted M DawsonNeuroregeneration Program, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205; Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205; Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21205.ORCID 0000-0002-6459-0893
Valina L DawsonNeuroregeneration Program, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205; Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205; Department of Physiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205.ORCID 0000-0002-2915-3970
Johns Hopkins University · USMRC Laboratory of Molecular Biology · GB
Funding
UNDERSTANDING NO SIGNALING RESULTING IN NEUROPROTECTION.P50DA000266 · NIDA · JOHNS HOPKINS UNIVERSITY · PI WORLEY, PAUL F · 1985 to 2017
$45.2MParthanatos, AIF and PAAN-1 in Neuronal InjuryR37NS067525 · NINDS · JOHNS HOPKINS UNIVERSITY · PI DAWSON, TED M., DAWSON, VALINA L. · 2015 to 2021
$5.3MA Novel Neuroprotective Protein, ThoraseR01AG029368 · NIA · JOHNS HOPKINS UNIVERSITY · PI DAWSON, VALINA L. · 2008 to 2012
$1.6MNIA NIH HHS R01 AG029368NIDA NIH HHS P50 DA000266NINDS NIH HHS R37 NS067525
Abstract
Neuronal loss caused by ischemic injury, trauma, or disease can lead to devastating consequences for the individual. With the goal of limiting neuronal loss, a number of cell death pathways have been studied, but there may be additional contributors to neuronal death that are yet unknown. To identify previously unknown cell death mediators, we performed a high-content genome-wide screening of short, interfering RNA (siRNA) with an siRNA library in murine neural stem cells after exposure to
Indexed as
AnimalsBrainCell DeathCell HypoxiaCells, CulturedComputational BiologyDisease Models, AnimalGlucoseInfarction, Middle Cerebral ArteryMaleMethylnitronitrosoguanidineMice, KnockoutMotor ActivityNeural Stem CellsNeuronsReceptors, CCR3Ccr3 protein, mouseGlucoseMethylnitronitrosoguanidineReceptors, CCR3excitotoxicityischemialibrary screenstroke
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What OpenQuestion holds
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LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.